Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye Hyeon | - |
dc.contributor.author | Jeong, Jin-Woo | - |
dc.contributor.author | Lee, Jun Hyuk | - |
dc.contributor.author | Kim, Gi-Young | - |
dc.contributor.author | Cheong, Jaehun | - |
dc.contributor.author | Jeong, Yong Kee | - |
dc.contributor.author | Yoo, Young Hyun | - |
dc.contributor.author | Choi, Yung Hyun | - |
dc.date.available | 2017-07-11T06:33:57Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3206 | - |
dc.description.abstract | Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis has been reported in various cancer cells. Cordycepin, a specific polyadenylation inhibitor, is the main functional component in Cordyceps militaris, which possesses many pharmacological activities including antitumor and anti-inflammation. In the present study, we demonstrated that treatment of cordycepin sensitized TRAIL-resistant Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis as evidenced by formation of apoptotic bodies, chromatin condensation and accumulation of cells in the sub-G1 phase. The induction of apoptosis following co-treatment with cordycepin and TRAIL in Hep3B cells appeared to be correlated with modulation of Bcl-2 family protein expression and activation of the caspase cascade, which resulted in the cleavage of poly(ADP-ribose) polymerase and β-catenin. In addition, cordycepin treatment also inhibited activation of c-Jun N-terminal kinase (JNK). Pretreatment with SP600125, a JNK inhibitor, resulted in a significantly increased sub-G1 population and caspase activity in cordycepin plus TRAIL-mediated apoptosis. Taken together, these results indicate that JNK acts as a key regulator of apoptosis in response to combined treatment with cordycepin and TRAIL in human hepatocellular carcinoma Hep3B cells. | - |
dc.publisher | Spandidos Publications | - |
dc.title | Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/or.2013.2589 | - |
dc.identifier.scopusid | 2-s2.0-84880610544 | - |
dc.identifier.bibliographicCitation | Oncology Reports, v.30, no.3, pp.1257 - 1264 | - |
dc.subject.keywordAuthor | cordycepin | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | Hep3B cells | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | c-Jun N-terminal kinase | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TNF | - |
dc.subject.keywordPlus | 3&apos | - |
dc.subject.keywordPlus | -DEOXYADENOSINE | - |
dc.subject.keywordPlus | POLYMERASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.citation.endPage | 1264 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1257 | - |
dc.citation.title | Oncology Reports | - |
dc.citation.volume | 30 | - |
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