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dc.contributor.authorBaek, Seung-Hoonko
dc.contributor.authorBae, Ok-Namko
dc.contributor.authorKim, Eun-Kyoungko
dc.contributor.authorYu, Seong-Woonko
dc.date.available2017-07-11T06:34:14Z-
dc.date.created2017-04-10-
dc.date.created2017-04-10-
dc.date.issued2013-09-
dc.identifier.citationMolecules and Cells, v.36, no.3, pp.258 - 266-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://hdl.handle.net/20.500.11750/3212-
dc.description.abstractPoly(ADP-ribose) polymerase-1 (PARP-1) mediates neuronal cell death in a variety of pathological conditions involving severe DNA damage. Poly(ADP-ribose) (PAR) polymer is a product synthesized by PARP-1. Previous studies suggest that PAR polymer heralds mitochondrial apoptosis-inducing factor (AIF) release and thereby, signals neuronal cell death. However, the details of the effects of PAR polymer on mitochondria remain to be elucidated. Here we report the effects of PAR polymer on mitochondria in cells in situ and isolated brain mitochondria in vitro. We found that PAR polymer causes depolarization of mitochondrial membrane potential and opening of the mitochondrial permeability transition pore early after injury. Furthermore, PAR polymer specifically induces AIF release, but not cytochrome c from isolated brain mitochondria. These data suggest PAR polymer as an endogenous mitochondrial toxin and will further our understanding of the PARP-1-dependent neuronal cell death paradigm. © The Korean Society for Molecular and Cellular Biology. All rights reserved.-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.subjectAnimal-
dc.subjectAnimal Cell-
dc.subjectAnimals-
dc.subjectApoptosis-
dc.subjectApoptosis-Inducing Factor-
dc.subjectBrain Mitochondrion-
dc.subjectC57Bl Mouse-
dc.subjectCell Viability-
dc.subjectControlled Study-
dc.subjectCytochrome C-
dc.subjectCytochromes C-
dc.subjectCytotoxicity-
dc.subjectEncephale Isole-
dc.subjectHela Cell-
dc.subjectHela Cell Line-
dc.subjectHela Cells-
dc.subjectHuman-
dc.subjectHuman Cell-
dc.subjectHumans-
dc.subjectIn Vitro Study-
dc.subjectMale-
dc.subjectMembrane Potential, Mitochondrial-
dc.subjectMetabolism-
dc.subjectMice, Inbred C57BL-
dc.subjectMitochondria-
dc.subjectMitochondrial Membrane-
dc.subjectMitochondrial Membrane Potential-
dc.subjectMitochondrial Membranes-
dc.subjectMitochondrial Permeability Transition Pore-
dc.subjectMitochondrion-
dc.subjectMouse-
dc.subjectNerve Cell-
dc.subjectNerve Cell Membrane Steady Potential-
dc.subjectNerve Cell Necrosis-
dc.subjectNeuronal Cell Death-
dc.subjectNeurons-
dc.subjectNicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase-
dc.subjectNon-Human-
dc.subjectParp1 Protein, Human-
dc.subjectPhysiology-
dc.subjectPoly(Adenosine Diphosphate Ribose)-
dc.subjectPoly(ADP-Ribose) Polymer-
dc.subjectPoly(ADP-Ribose) Polymerase-1, Mouse-
dc.subjectPoly(ADP-Ribose) Polymerase 1, Mouse-
dc.subjectPoly(ADP-Ribose) Polymerases-
dc.subjectPolymer-
dc.subjectPolymers-
dc.subjectUnclassified Drug-
dc.titleInduction of mitochondrial dysfunction by poly(ADP-ribose) polymer: Implication for neuronal cell death-
dc.typeArticle-
dc.identifier.doi10.1007/s10059-013-0172-0-
dc.identifier.wosid000324643100010-
dc.identifier.scopusid2-s2.0-84898143711-
dc.type.localArticle(Overseas)-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.kciidART001804123-
dc.contributor.localauthorKim, Eun-Kyoung-
dc.contributor.localauthorYu, Seong-Woon-
dc.contributor.nonIdAuthorBaek, Seung-Hoon-
dc.contributor.nonIdAuthorBae, Ok-Nam-
dc.identifier.citationVolume36-
dc.identifier.citationNumber3-
dc.identifier.citationStartPage258-
dc.identifier.citationEndPage266-
dc.identifier.citationTitleMolecules and Cells-
dc.type.journalArticleArticle-
dc.description.isOpenAccessN-


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