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Activity of the mitochondrial calcium uniporter varies greatly between tissues
- Activity of the mitochondrial calcium uniporter varies greatly between tissues
- Fieni, Francesca; Lee, Sung Bae; Jan, Yuhnung; Kirichok, Yuriy V.
- DGIST Authors
- Lee, Sung Bae
- Issue Date
- Nature Communications, 3, 1317
- Article Type
- Animal Experiment; Animal Tissue; Apoptosis; Brown Adipose Tissue; Calcium; Calcium Current; Calcium Transport; Cell Volume; Comparative Study; Flight Muscle; Heart Mitochondrion; Kidney; Liver; Membrane; Metabolism; Mitochondrial DNA; Mitochondrial Membrane; Mouse; Non-Human; Rodent; Skeletal Muscle
- The mitochondrial calcium uniporter is a highly selective channel responsible for mitochondrial Ca 2+uptake. The mitochondrial calcium uniporter shapes cytosolic Ca 2+signals, controls mitochondrial ATP production, and is involved in cell death. Here using direct patch-clamp recording from the inner mitochondrial membrane, we compare mitochondrial calcium uniporter activity in mouse heart, skeletal muscle, liver, kidney and brown fat. Surprisingly, heart mitochondria show a dramatically lower mitochondrial calcium uniporter current density than the other tissues studied. Similarly, in Drosophila flight muscle, mitochondrial calcium uniporter activity is barely detectable compared with that in other fly tissues. As mitochondria occupy up to 40% of the cell volume in highly metabolically active heart and flight muscle, low mitochondrial calcium uniporter activity is likely essential to avoid cytosolic Ca 2+sink due to excessive mitochondrial Ca 2+uptake. Simultaneously, low mitochondrial calcium uniporter activity may also prevent mitochondrial Ca 2+overload in such active tissues exposed to frequent cytosolic Ca 2+activity. © 2012 Macmillan Publishers Limited. All rights reserved.
- Nature Publishing Group
- Related Researcher
Lee, Sung Bae
SB LAB(Lab of Neurodegenerative diseases and Aging)
Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
- Department of Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles
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