Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Van Du Nguyen | - |
dc.contributor.author | Zheng, Shaohui | - |
dc.contributor.author | Han, Jiwon | - |
dc.contributor.author | Viet Ha Le | - |
dc.contributor.author | Park, Jong-Oh | - |
dc.contributor.author | Park, Sukho | - |
dc.date.available | 2017-08-10T08:11:48Z | - |
dc.date.created | 2017-08-09 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | Colloids and Surfaces B: Biointerfaces, v.154, pp.104 - 114 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4159 | - |
dc.description.abstract | The aim of this work is to prepare and evaluate a novel lipid-polymer hybrid liposomal nanoplatform (hyaluronic acid-magnetic nanoparticle-liposomes, HA-MNP-LPs) as a vehicle for targeted delivery and triggered release of an anticancer drug (docetaxel, DTX) in human breast cancer cells. We first synthesize an amphiphilic hyaluronic acid hexadecylamine polymer (HA-C-16) to enhance the targeting ability of the hybrid liposome. Next, HA-MNP-LPs are constructed to achieve an average size of 189.93 +/- 2.74 nm in diameter. In addition, citric acid-coated magnetic nanoparticles (MNPs) are prepared and embedded in the aqueous cores while DTX is encapsulated in the hydrophobic bilayers of the liposomes. Experiments with coumarin 6 loaded hybrid liposomes (C6/HA-MNP-LPs) show that the hybrid liposomes have superior cellular uptake in comparison with the conventional non-targeting liposomes (C6/MNP-LPs), and the result is further confirmed by Prussian blue staining. Under near-infrared laser irradiation (NIR, 808 nm), the HA-MNP-LPs aqueous solution can reach 46.7 degrees C in 10 min, and the hybrid liposomes released over 20% more drug than the non-irradiated liposomes. Using a combination of photothermal irradiation and chemotherapy, the DTX-loaded hybrid liposomes (DTX/HA-MNP-LPs) significantly enhance therapeutic efficacy, with the IC50 value of 0.69 +/- 0.10 mu g/mL, which is much lower than the values for DTX monotherapy. Consequently, the prepared hybrid nanoplatform may offer a promising drug delivery vehicle with selective targeting and enhanced drug release in treating CD44-overexpressing cancers. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.title | Nanohybrid magnetic liposome functionalized with hyaluronic acid for enhanced cellular uptake and near-infrared-triggered drug release | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2017.03.008 | - |
dc.identifier.wosid | 000402348000014 | - |
dc.identifier.scopusid | 2-s2.0-85015444020 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Colloids and Surfaces B: Biointerfaces | - |
dc.contributor.nonIdAuthor | Van Du Nguyen | - |
dc.contributor.nonIdAuthor | Zheng, Shaohui | - |
dc.contributor.nonIdAuthor | Han, Jiwon | - |
dc.contributor.nonIdAuthor | Viet Ha Le | - |
dc.contributor.nonIdAuthor | Park, Jong-Oh | - |
dc.identifier.citationVolume | 154 | - |
dc.identifier.citationStartPage | 104 | - |
dc.identifier.citationEndPage | 114 | - |
dc.identifier.citationTitle | Colloids and Surfaces B: Biointerfaces | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Nanohybrid liposome | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
dc.subject.keywordAuthor | Targeted drug delivery | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | CD44 receptor | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordPlus | POLYMER HYBRID NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED CO-DELIVERY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | CLINICAL-APPLICATIONS | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | SENSITIVE LIPOSOMES | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | ANTICANCER DRUGS | - |
dc.subject.keywordPlus | COATED LIPOSOMES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.contributor.affiliatedAuthor | Van Du Nguyen | - |
dc.contributor.affiliatedAuthor | Zheng, Shaohui | - |
dc.contributor.affiliatedAuthor | Han, Jiwon | - |
dc.contributor.affiliatedAuthor | Viet Ha Le | - |
dc.contributor.affiliatedAuthor | Park, Jong-Oh | - |
dc.contributor.affiliatedAuthor | Park, Sukho | - |
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