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The HOOK region of subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane

Title
The HOOK region of subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane
Authors
박천규서병창
DGIST Authors
박천규; 서병창
Issue Date
2017-06
Citation
Channels, 11(5), 467-475
Type
Article
Article Type
Article
Keywords
Current DensityElectrostatic InteractionHook RegionPlasma MembraneVoltage Dependent GatingVoltage Gated Ca2+ (CaV) ChannelBeta 2c Subunit
ISSN
1933-6950
Abstract
Recently, we showed that the HOOK region of the β2 subunit electrostatically interacts with the plasma membrane and regulates the current inactivation and phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of voltage-gated Ca2+ (CaV) 2.2 channels. Here, we report that voltage-dependent gating and current density of the CaV2.2 channels are also regulated by the HOOK region of the β2 subunit. The HOOK region can be divided into 3 domains: S (polyserine), A (polyacidic), and B (polybasic). We found that the A domain shifted the voltage-dependent inactivation and activation of CaV2.2 channels to more hyperpolarized and depolarized voltages, respectively, whereas the B domain evoked these responses in the opposite directions. In addition, the A domain decreased the current density of the CaV2.2 channels, while the B domain increased it. Together, our data demonstrate that the flexible HOOK region of the β2 subunit plays an important role in determining the overall CaV channel gating properties. © 2017 Taylor & Francis
URI
http://hdl.handle.net/20.500.11750/4266
DOI
10.1080/19336950.2017.1335841
Publisher
Taylor and Francis Inc.
Related Researcher
  • Author Suh, Byung Chang Current Lab
  • Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
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Collection:
Department of Brain and Cognitive SciencesCurrent Lab1. Journal Articles


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