Cited 2 time in
Cited 3 time in
The HOOK region of subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane
- The HOOK region of subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane
- 박천규; 서병창
- DGIST Authors
- 박천규; 서병창
- Issue Date
- Channels, 11(5), 467-475
- Article Type
- Current Density; Electrostatic Interaction; Hook Region; Plasma Membrane; Voltage Dependent Gating; Voltage Gated Ca2+ (CaV) Channel; Beta 2c Subunit
- Recently, we showed that the HOOK region of the β2 subunit electrostatically interacts with the plasma membrane and regulates the current inactivation and phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of voltage-gated Ca2+ (CaV) 2.2 channels. Here, we report that voltage-dependent gating and current density of the CaV2.2 channels are also regulated by the HOOK region of the β2 subunit. The HOOK region can be divided into 3 domains: S (polyserine), A (polyacidic), and B (polybasic). We found that the A domain shifted the voltage-dependent inactivation and activation of CaV2.2 channels to more hyperpolarized and depolarized voltages, respectively, whereas the B domain evoked these responses in the opposite directions. In addition, the A domain decreased the current density of the CaV2.2 channels, while the B domain increased it. Together, our data demonstrate that the flexible HOOK region of the β2 subunit plays an important role in determining the overall CaV channel gating properties. © 2017 Taylor & Francis
- Taylor and Francis Inc.
- Related Researcher
Laboratory of Brain Signal and Synapse Research
Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
There are no files associated with this item.
- Department of Brain and Cognitive SciencesLaboratory of Brain Signal and Synapse Research1. Journal Articles
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.