Cited 11 time in webofscience Cited 16 time in scopus

Histone lysine methylation and neurodevelopmental disorders

Title
Histone lysine methylation and neurodevelopmental disorders
Authors
Kim, Jeong-HoonLee, Jang HoLee, Im-SoonLee, Sung BaeCho, Kyoung Sang
DGIST Authors
Lee, Sung Bae
Issue Date
2017-06
Citation
International Journal of Molecular Sciences, 18(7)
Type
Article
Article Type
Review
ISSN
1661-6596
Abstract
Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/4273
DOI
10.3390/ijms18071404
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
  • Author Lee, Sung-Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles


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