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dc.contributor.author Kim, Jeong-Hoon -
dc.contributor.author Lee, Jang Ho -
dc.contributor.author Lee, Im-Soon -
dc.contributor.author Lee, Sung Bae -
dc.contributor.author Cho, Kyoung Sang -
dc.date.available 2017-08-10T08:19:35Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-07 -
dc.identifier.issn 1661-6596 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4273 -
dc.description.abstract Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. -
dc.language English -
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) -
dc.title Histone lysine methylation and neurodevelopmental disorders -
dc.type Article -
dc.identifier.doi 10.3390/ijms18071404 -
dc.identifier.scopusid 2-s2.0-85021636543 -
dc.identifier.bibliographicCitation International Journal of Molecular Sciences, v.18, no.7 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordAuthor epigenetic changes -
dc.subject.keywordAuthor histone lysine methylation -
dc.subject.keywordAuthor lysine methyltransferase -
dc.subject.keywordAuthor lysine demethylase -
dc.subject.keywordAuthor neurodevelopmental disorder -
dc.subject.keywordPlus LINKED MENTAL-RETARDATION -
dc.subject.keywordPlus OF-FUNCTION VARIANTS -
dc.subject.keywordPlus DEVELOPMENTAL REGULATORS -
dc.subject.keywordPlus INTELLECTUAL DISABILITY -
dc.subject.keywordPlus CHROMATIN MODIFICATIONS -
dc.subject.keywordPlus EPIGENETIC REGULATION -
dc.subject.keywordPlus OVERGROWTH SYNDROME -
dc.subject.keywordPlus H3K27 METHYLATION -
dc.subject.keywordPlus WEAVER SYNDROME -
dc.subject.keywordPlus UNUSUAL FACIES -
dc.citation.number 7 -
dc.citation.title International Journal of Molecular Sciences -
dc.citation.volume 18 -
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Appears in Collections:
Department of Brain Sciences Laboratory of Neurodegenerative Diseases and Aging 1. Journal Articles

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