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dc.contributor.author Kim, Jeong-Hoon ko
dc.contributor.author Lee, Jang Ho ko
dc.contributor.author Lee, Im-Soon ko
dc.contributor.author Lee, Sung Bae ko
dc.contributor.author Cho, Kyoung Sang ko
dc.date.available 2017-08-10T08:19:35Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-06 -
dc.identifier.citation International Journal of Molecular Sciences, v.18, no.7 -
dc.identifier.issn 1661-6596 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4273 -
dc.description.abstract Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. -
dc.language English -
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) -
dc.title Histone lysine methylation and neurodevelopmental disorders -
dc.type Article -
dc.identifier.doi 10.3390/ijms18071404 -
dc.identifier.wosid 000408746800076 -
dc.identifier.scopusid 2-s2.0-85021636543 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.contributor.nonIdAuthor Kim, Jeong-Hoon -
dc.contributor.nonIdAuthor Lee, Jang Ho -
dc.contributor.nonIdAuthor Lee, Im-Soon -
dc.contributor.nonIdAuthor Cho, Kyoung Sang -
dc.identifier.citationVolume 18 -
dc.identifier.citationNumber 7 -
dc.identifier.citationTitle International Journal of Molecular Sciences -
dc.type.journalArticle Review -
dc.description.isOpenAccess Y -
dc.contributor.affiliatedAuthor Lee, Sung Bae -
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Appears in Collections:
Department of Brain Sciences Laboratory of Neurodegenerative Diseases and Aging 1. Journal Articles

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