Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
- Title
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
- Author(s)
- Han, Kyung Ah ; Ko, Jaewon
- Issued Date
- 2023-06
- Citation
- Experimental and Molecular Medicine, v.55, no.6, pp.1065 - 1075
- Type
- Article
- Keywords
- RETARDATION PROTEIN FMRP ; DENDRITIC SPINES ; ARP2/3 COMPLEX ; POSTSYNAPTIC DENSITY ; SCAR/WAVE PROTEINS ; N-WASP ; DYNAMICS ; PHOSPHORYLATION ; CYFIP1 ; CYTOSKELETON
- ISSN
- 1226-3613
- Abstract
- The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders. © 2023, The Author(s).
- Publisher
- Springer Nature
- Related Researcher
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Ko, Jaewon 뇌과학과
- Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
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- Appears in Collections:
- Department of Brain Sciences Laboratory of Synapse Formation and Function 1. Journal Articles
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