Cited time in webofscience Cited time in scopus

Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses

Title
Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses
Author(s)
Jung, HyejiKim, SeungjoonKo, JaewonUm, Ji Won
Issued Date
2023-08
Citation
Current Opinion in Neurobiology, v.81
Type
Article
Author Keywords
GABAergic signalingGABAGABAergic synapseBrain disordersGephyrin
Keywords
INTELLECTUAL DISABILITYSOMATOSTATIN EXPRESSIONSYNAPTIC-TRANSMISSIONCOLLYBISTINGEPHYRINACTIVATIONPLASTICITYCDC42PHOSPHORYLATIONMAINTENANCE
ISSN
0959-4388
Abstract
Postsynaptic GABAergic receptors interact with various membrane and intracellular proteins to mediate inhibitory synaptic transmission. They form structural and/or signaling synaptic protein complexes that perform a variety of postsynaptic functions. In particular, the key GABAergic synaptic scaffold, gephyrin, and its interacting partners govern downstream signaling pathways that are essential for GABAergic synapse development, transmission, and plasticity. In this review, we discuss recent researches on GABAergic synaptic signaling pathways. We also outline the main outstanding issues that need to be addressed in this field and highlight the association of dysregulated GABAergic synaptic signaling with the onset of various brain disorders. © 2023 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/46133
DOI
10.1016/j.conb.2023.102728
Publisher
Elsevier
Related Researcher
  • 고재원 Ko, Jaewon
  • Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences Laboratory of Synapse Formation and Function 1. Journal Articles
Department of Brain Sciences Synapse Disorder Laboratory 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE