Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hong, Myeongjin | - |
dc.contributor.author | Ryu, Leesun | - |
dc.contributor.author | Ow, Maria C. | - |
dc.contributor.author | Kim, Jinmahn | - |
dc.contributor.author | Je, A. Reum | - |
dc.contributor.author | Chinta, Satya | - |
dc.contributor.author | Huh, Yang Hoon | - |
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Butcher, Rebecca A. | - |
dc.contributor.author | Choi, Hongsoo | - |
dc.contributor.author | Sengupta, Piali | - |
dc.contributor.author | Hall, Sarah E. | - |
dc.contributor.author | Kim, Kyuhyung | - |
dc.date.available | 2017-10-30T04:20:11Z | - |
dc.date.created | 2017-10-30 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4631 | - |
dc.description.abstract | Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3–7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses. Hong et al. show that early pheromone experience in C. elegans hermaphrodites is imprinted via alteration of activity of a single synaptic connection and, in turn, modulates behavioral responses to the pheromone as adults. © 2017 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cub.2017.08.068 | - |
dc.identifier.scopusid | 2-s2.0-85030626216 | - |
dc.identifier.bibliographicCitation | Current Biology, v.27, no.20, pp.3168 - 3177.e3 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | GPI-anchored protein | - |
dc.subject.keywordAuthor | neuronal activity | - |
dc.subject.keywordAuthor | pheromone | - |
dc.subject.keywordAuthor | sensory imprinting | - |
dc.subject.keywordAuthor | synapse | - |
dc.subject.keywordPlus | NEMATODE CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | OLFACTORY MEMORY | - |
dc.subject.keywordPlus | NEURAL CIRCUITS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | NEURONS | - |
dc.citation.endPage | 3177.e3 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 3168 | - |
dc.citation.title | Current Biology | - |
dc.citation.volume | 27 | - |
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