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dc.contributor.author Jung, Inseong -
dc.contributor.author Shin, Sanghee -
dc.contributor.author Baek, Moon-Chang -
dc.contributor.author Yea, Kyungmoo -
dc.date.accessioned 2024-02-21T09:40:15Z -
dc.date.available 2024-02-21T09:40:15Z -
dc.date.created 2024-01-11 -
dc.date.issued 2024-02 -
dc.identifier.issn 1226-3613 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/47968 -
dc.description.abstract Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant tumors by harnessing the body’s immune system to selectively target cancer cells. Despite remarkable advances, there are still challenges in achieving successful clinical responses. Recent evidence suggests that immune cell-derived exosomes modulate the immune system to generate effective antitumor immune responses, making them a cutting-edge therapeutic strategy. However, natural exosomes are limited in clinical application due to their low drug delivery efficiency and insufficient antitumor capacity. Technological advancements have allowed exosome modifications to magnify their intrinsic functions, load different therapeutic cargoes, and preferentially target tumor sites. These engineered exosomes exert potent antitumor effects and have great potential for cancer immunotherapy. In this review, we describe ingenious modification strategies to attain the desired performance. Moreover, we systematically summarize the tumor-controlling properties of engineered immune cell-derived exosomes in innate and adaptive immunity. Collectively, this review provides a comprehensive and intuitive guide for harnessing the potential of modified immune cell-derived exosome-based approaches, offering valuable strategies to enhance and optimize cancer immunotherapy. © 2023, The Author(s). -
dc.language English -
dc.publisher Springer Nature -
dc.title Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications -
dc.type Article -
dc.identifier.doi 10.1038/s12276-023-01132-8 -
dc.identifier.wosid 001135877200005 -
dc.identifier.scopusid 2-s2.0-85181246886 -
dc.identifier.bibliographicCitation Experimental and Molecular Medicine, v.56, no.1, pp.19 - 31 -
dc.identifier.kciid ART003048359 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordPlus NATURAL-KILLER-CELLS -
dc.subject.keywordPlus EXTRACELLULAR VESICLES -
dc.subject.keywordPlus DENDRITIC CELLS -
dc.subject.keywordPlus ENGINEERING EXOSOMES -
dc.subject.keywordPlus B-CELLS -
dc.subject.keywordPlus PACLITAXEL -
dc.subject.keywordPlus VACCINE -
dc.subject.keywordPlus INDUCE -
dc.subject.keywordPlus INFLAMMATION -
dc.subject.keywordPlus NEUTROPHILS -
dc.citation.endPage 31 -
dc.citation.number 1 -
dc.citation.startPage 19 -
dc.citation.title Experimental and Molecular Medicine -
dc.citation.volume 56 -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Research & Experimental Medicine -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Medicine, Research & Experimental -
dc.type.docType Review -
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Appears in Collections:
Department of New Biology Bio-therapeutics Design Lab 1. Journal Articles

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