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Proteomics in Rheumatoid Arthritis Research

Title
Proteomics in Rheumatoid Arthritis Research
Authors
Park, Yune-JungChung, Min KyungHwang, Dae HeeKim, Wan-Uk
DGIST Authors
Hwang, Dae Hee
Issue Date
2015-08
Citation
Immune Network, 15(4), 177-185
Type
Article
Keywords
Rheumatoid arthritisProteomicsBiomarker
ISSN
1598-2629
Abstract
Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the largescale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
URI
http://hdl.handle.net/20.500.11750/4903
DOI
10.4110/in.2015.15.4.177
Publisher
대한면역학회
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
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Collection:
Department of New BiologySystems Biology and Medicine Lab1. Journal Articles


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