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Morphological evidences in circumvallate papilla and von Ebners’ gland development in mice

Title
Morphological evidences in circumvallate papilla and von Ebners’ gland development in mice
Translated Title
Bae, Y. C. Bae, Yong Chul
Authors
Bae, Yong ChulYamamoto, HitoshiLee, Sang GyuKim, Jae YoungSohn, Wern JooGwon, Gi JeongAn, Chang HyeonMoon, Che Il
DGIST Authors
Moon, Che Il
Issue Date
2011
Citation
Anatomy and Cell Biology, 44(4), 274-283
Type
Article
Keywords
Circumvallate papillavon Ebners glandsEpithelial diff erentiationAM1-43 microinjections3D computer-aided reconstruction
ISSN
2093-3665
Abstract
In rodents, the circumvallate papilla (CVP), with its underlying minor salivary gland, the von Ebners’ gland (VEG),is located on the dorsal surface of the posterior tongue. Detailed morphological processes to form the proper structure of CVP and VEG have not been properly elucidated. In particular, the specifi c localization patterns of taste buds in CVP and the branching formation of VEG have not yet been elucidated. To understand the developmental mechanisms underlying CVP and VEG formation, detailed histological observations of CVP and VEG were examined using a three-dimensional computeraided reconstruction method with serial histological sections and pan-Cytokeratins immunostainings. In addition, to defi ne the developmental processes in CVP and VEG formation, we examined nerve innervations and cell proliferation using microinjections of AM1-43 and immunostainings with various markers, including phosphoinositide 3-kinase, Ki-67, PGP9.5,and Ulex europaeus agglutinin 1 (UEA1). Results revealed specifi c morphogenesis of CVP and VEG with nerve innervations patterns, evaluated by the coincided localization patterns of AM1-43 and UEA1. Based on these morphological and immunohistochemical results, we suggest that nerve innervations and cell proliferations play important roles in the positioning of taste buds in CVP and branching morphogenesis of VEG in tongue development.
URI
http://hdl.handle.net/20.500.11750/4988
DOI
10.5115/acb.2011.44.4.274
Publisher
대한해부학회
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


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