Cited 5 time in webofscience Cited 0 time in scopus

Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division

Title
Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division
Authors
Cho, BongkiCho, Hyo MinJo, YouhwaKim, Hee DaeSong, MyungjaeMoon, CheilKim, HyongbumKim, KyungjinSesaki, HiromiRhyu, Im JooKim, HyunSun, Woong
DGIST Authors
Moon, Cheil
Issue Date
2017-06-09
Citation
Nature Communications, 8
Type
Article
Article Type
Article
Keywords
DRP1DynaminFissionFusionMembraneOPA1Oxidative PhosphorylationProteinRecruitmentReticulum
ISSN
2041-1723
Abstract
Mitochondrial division is critical for the maintenance and regulation of mitochondrial function, quality and distribution. This process is controlled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitochondrial outer membrane (OMM). Although mitochondrial physiology, including oxidative phosphorylation, is also important for efficient mitochondrial division, morphological alterations of the mitochondrial inner-membrane (IMM) have not been clearly elucidated. Here we report spontaneous and repetitive constriction of mitochondrial inner compartment (CoMIC) associated with subsequent division in neurons. Although CoMIC is potentiated by inhibition of Drp1 and occurs at the potential division spots contacting the endoplasmic reticulum, it appears on IMM independently of OMM. Intra-mitochondrial influx of Ca2+ induces and potentiates CoMIC, and leads to K+-mediated mitochondrial bulging and depolarization. Synergistically, optic atrophy 1 (Opa1) also regulates CoMIC via controlling Mic60-mediated OMM-IMM tethering. Therefore, we propose that CoMIC is a priming event for efficient mitochondrial division.
URI
http://hdl.handle.net/20.500.11750/5002
DOI
10.1038/ncomms15754
Publisher
NATURE PUBLISHING GROUP
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE