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Thiol-Responsive Micelles Based on Nonionic Gemini Surfactants with a Cystine Disulfide Spacer

Title
Thiol-Responsive Micelles Based on Nonionic Gemini Surfactants with a Cystine Disulfide Spacer
Authors
Kim, Hyun-ChulKim, EunjooLee, Se GuenLee, Sung JunKim, HyunminJeong, Sang Won
DGIST Authors
Kim, Hyun-ChulKim, EunjooLee, Se GuenLee, Sung JunKim, HyunminJeong, Sang Won
Issue Date
2014-02-15
Citation
Journal of Polymer Science, Part A: Polymer Chemistry, 52(4), 582-589
Type
Article
Article Type
Article
Keywords
Average DiameterBiodegradableBiodegradable PolymersCritical Micelle Concentration (CMC)CystinesDisulfide-Thiol ExchangeDisulfide-Thiol ExchangesDrug DeliveryDrug Delivery SystemDrug Delivery SystemsEntrapment EfficiencyGel Permeation ChromatographyGemini SurfactantGlutathionesMicellesMotion Picture Experts Group StandardsNon-Ionic SurfactantsStimuli-Sensitive PolymersSulfur CompoundsSurface Active AgentsSurfactants
ISSN
0887-624X
Abstract
Thiol-responsive micelles consisting of novel nonionic gemini surfactants with a cystine disulfide spacer are reported. The gemini surfactants, (C 18-Cys-mPEG)2 and ((C18)2-Lys-Cys- mPEG)2, were synthesized from polyethylene glycol, cysteine, and stearic acid, and their structures were confirmed by 1H NMR and gel permeation chromatography. (C18-Cys-mPEG)2 and ((C 18)2-Lys-Cys-mPEG)2 formed micelles with average diameters of 13 and 22 nm above the critical micelle concentration of 6.5 and 4.7 μg mL-1, respectively. The micelles of ((C 18)2-Lys-Cys-mPEG)2 containing more stearoyl groups showed encapsulated more hydrophobic indomethacin (IMC) with higher entrapment efficiencies than those of (C18-Cys-mPEG)2. The gemini surfactant micelles exhibited an accelerated release of encapsulated IMC with the concentration of the reducing agent, glutathione (GSH), whereas they were unaffected by the presence of reduced GSH (GSSG). The 3-(4,5- dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium studies revealed the noncytotoxic nature of the gemini surfactant micelles. © 2013 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11750/5266
DOI
10.1002/pola.27036
Publisher
Wiley Blackwell
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, nanomedicine, molecular diagnosis
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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