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Synaptic functions of the IQSEC family of ADP-ribosylation factor guanine nucleotide exchange factors

Title
Synaptic functions of the IQSEC family of ADP-ribosylation factor guanine nucleotide exchange factors
Authors
Um, Ji Won
DGIST Authors
Um, Ji Won
Issue Date
2017-03
Citation
Neuroscience Research, 116, 54-59
Type
Article
Article Type
Review
Keywords
SEVERE INTELLECTUAL DISABILITYPOSTSYNAPTIC DENSITY FRACTIONEXCITATORY SYNAPSESCELL-ADHESIONMOUSE RETINAARF FAMILYG-PROTEINSMUTATIONSACTIVATIONPSD-95
ISSN
0168-0102
Abstract
Postsynaptic scaffolding proteins interact with numerous synaptic proteins to ensure the organization and specialization of functional excitatory and inhibitory synapses. IQSECs (IQ motif and SEC7 domain-containing proteins) are a class of ADP ribosylation factor-guanine nucleotide exchange factors (ARF-GEFs), whose functions are beginning to be understood as both scaffolding and signaling proteins. Specifically, IQSEC1 binds to PSD-95, and IQSEC2 functions as a regulator of AMPA receptor trafficking at excitatory synapses, whereas IQSEC3 interacts with gephyrin to promote inhibitory synapse development. Here, I review the currently known findings on IQSECs and discuss the possible relations between dysfunctions of IQSECs and the pathophysiology of brain disorders. © 2016 Elsevier Ireland Ltd and Japan Neuroscience Society
URI
http://hdl.handle.net/20.500.11750/5657
DOI
10.1016/j.neures.2016.06.007
Publisher
ELSEVIER IRELAND LTD
Related Researcher
  • Author Um, Ji Won Um Laboratory
  • Research Interests Molecular and cellular mechanisms underlying synapse elimination; Key synaptic mechanisms associated with Alzheimer's disease and autism spectrum disorders; Synaptic homeostasis
Files:
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Collection:
Department of Brain and Cognitive SciencesUm Laboratory1. Journal Articles


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