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Ultrasound-Assisted Photothermal Therapy (ULTRA-PTT) for the Treatment of Deep-Seated Tumors

Title
Ultrasound-Assisted Photothermal Therapy (ULTRA-PTT) for the Treatment of Deep-Seated Tumors
Author(s)
Kim, HaeminKim, JinwooSeo, An NaChang, Jin Ho
Issued Date
ACCEPT
Citation
Advanced Optical Materials
Type
Article
Author Keywords
deep seated tumorslasersphotothermal therapytherapeutic handpieceultrasound
Keywords
OPTICAL-PROPERTIESGRAPHENETISSUELASERMECHANISMSABLATIONSKIN
ISSN
2195-1071
Abstract
Photothermal therapy (PTT) has garnered considerable attention as an attractive treatment tool for cancer due to precisely selective treatment and minimal side effects. The primary challenge of PTT, which hinders its widespread application, is the limited therapeutic depth. This limitation arises from optical scattering in biological tissues, causing inadequate heat distribution within the deep tissue. To overcome this challenge, ultrasound-assisted PTT (ULTRA-PTT) is proposed that leverages the temporary formation of gas bubbles induced by ultrasound within the light propagation path. These bubbles act as optical clearing agents, effectively reducing optical scattering in biological tissues. To facilitate ULTRA-PTT, a dedicated handpiece consisting of a ring-shaped ultrasound transducer and a laser delivery module is developed. In-vivo experiments show that ULTRA-PTT statistically outperforms conventional PTT in melanoma treatment, mostly due to its ability to deliver sufficient laser energy to deep-seated cancer cells. These findings underscore the potential of ULTRA-PTT to expand the clinical applications of PTT beyond local tumors occurring in superficial tissue. © 2024 Wiley-VCH GmbH.
URI
http://hdl.handle.net/20.500.11750/56697
DOI
10.1002/adom.202400332
Publisher
Wiley
Related Researcher
  • 장진호 Chang, Jin Ho
  • Research Interests Biomedical Imaging; Signal and Image Processing; Ultrasound Imaging System; Ultrasound Transducer; Photoacoustic Imaging
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Appears in Collections:
Department of Electrical Engineering and Computer Science Medical Acoustic Fusion Innovation Lab. 1. Journal Articles

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