능동 전달 및 약물 방출을 위한 점막 접착 패치 개발

Abstract

Drug delivery in the gastrointestinal tract has been variously studied, and improving drug delivery efficiency is an important issue. In this paper, we propose a drug-loaded mucoadhesive patch capable of active delivery and drug release promotion. The proposed mucoadhesive patch has excellent adhesion even in the wet intestinal environment and is capable of hyperthermia and drug release promotion. The proposed patch is mounted in our wireless capsule with open-close mechanism and can be actively delivered to two or more lesions. The possibility of patch delivery to the gastrointestinal tract was verified through an ex-vivo test using porcine small intestine. In addition, cytotoxicity experiments using HT-29 cells were performed to confirm the cancer cell-killing.