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Characterization of Mice Deficient of Leukaemia Inhibitory Factor

Title
Characterization of Mice Deficient of Leukaemia Inhibitory Factor
Authors
문제일
DGIST Authors
문제일
Issue Date
2006-12
Citation
Laboratory Animal Research, 22(4), 397-400
Type
Article
Keywords
Leukemia inhibitory factortransgenic mouseKO mouse
ISSN
1738-6055
Abstract
Leukemia inhibitory factor (LIF) is a multifunctional neuropoietic cytokine involved in neuronal development. Mice with target disruption of the LIF gene are available due to transgenic technology and biotechnology. However, LIF-deficient mice have been reported to be embarrassingly poor in replacement and display awkward colony phenotypes. From total 265 breeds, significantly smaller breeding rate and litter numbers were observed from homozygous male pairs. And LIF-deficient mouse colony did not follow rules of genetics. Both heterozygote male and homozygote male colonies showed significantly higher male birth rate than the hypothetical value. Taken together, epochal improvement in acquiring transgenic animals may be necessary to facilitate large-scale or long-term studies using the LIF-deficient mice. Therefore, better strategies to assure enough numbers of LIF-deficient mice are imminent. In order to achieve this goal, longterm monitoring of the colony has been performed and possible solutions also have been suggested.
URI
http://hdl.handle.net/20.500.11750/5757
Publisher
한국실험동물학회
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


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