Magnetically Actuated Capsule with Multiple Sampling Capability for Gut Microbiome Research

Abstract

Understanding the relationship between gut microbiota and gastrointestinal (GI) diseases through longitudinal analysis is vital for advancing diagnosis and treatment methods. To achieve this, ingestible devices capable of multipoint gut microbiota sampling are necessary. Conventional devices move passively through the GI tract, relying on physiological factors and are unable to perform multipoint sampling. This study introduces a novel magnetically actuated capsule robot designed to collect gut microbiota from various GI tract locations while minimizing cross-contamination. The capsule includes a body, a driving unit, six sampling tools, a central rod, and two heads. It uses electromagnetic field control for precise orientation and position of the capsule, ensuring the sampling channel faces downward for accurate collection. The capsule can collect six distinct microbiota samples, protecting the tools from contamination throughout the process. Its active locomotion and sampling capabilities were tested through ex-vivo tests. The feasibility of clinical application was demonstrated in preclinical trials using a porcine model, confirming the capsule's potential for integration and use in medical settings. © 2024 ICROS.