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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김규형 | - |
| dc.contributor.author | Kyeong Min Moon | - |
| dc.date.accessioned | 2025-02-28T21:00:49Z | - |
| dc.date.available | 2025-08-31T06:00:28Z | - |
| dc.date.issued | 2025 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/57949 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000837686 | - |
| dc.description | C. elegans, Gait transition, SMB neuron, unc-29, unc-79 | - |
| dc.description.tableofcontents | List of Contents Abstract i List of contents ii List of tables iv List of figures v Ⅰ. INTRODUCTION 1.1 Locomotion in animals 1 1.2 Gait transition in animals 1 1.3 Locomotion in C. elegans 3 1.4 Gait transition in C. elegans 5 1.5 Summary 6 Ⅱ. MATERIALS AND METHODS Ⅲ. RESULTS 3.1 Characteristics of different types of locomotive strategies in C. elegans 25 3.2 Gait transition is mediated by the head motor neuron SMB and SMD 31 3.3 The SMB neurons control head muscle activity to restrict head locomotion 42 3.4 Isolation of mutant strains that exhibit abnormal gait transition and swimming behavior 47 3.5 NCA complex protein UNC-79 regulates gait transition and swimming behavior 53 3.6 Acetylcholine receptor protein UNC-29 has a role in gait transition and swimming behavior 64 3.7 Gait transition-induced calcium activity of body muscles is mediated by nAChR 73 3.8 unc-29 may act downstream of SMB-mediated head muscle control in gait transition and swimming 77 3.9 Candidate neurotransmitter in gait transition 79 3.10 Candidate sensory neurons in gait transition 79 Ⅳ. DISCUSSIONS 4.1 Crawling-to-Swimming transition is regulated by head motor neurons: SMB and SMD 84 4.2 NCA channel subunit gene unc-79 regulates body locomotion to mediate gait transition and sustenance of gaits. 85 4.3 nAChR subunit unc-29 gene in muscles regulates Ca2+ activity to mediate proper gaits 86 4.4 Selecting gaits are regulated by complex neural circuit mechanisms in C. elegans 87 Ⅴ. REFERENCES Ⅵ. SUMMARY IN KOREANS VII. APPENDIX A FMRFamide-like neuropeptide FLP-12 signaling regulates head locomotive behaviors in Caenorhabditis elegans 99 |
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| dc.format.extent | 112 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Circuit mechanisms underlying gait switching in C. elegans | - |
| dc.title.alternative | 예쁜 꼬마 선충을 이용한 환경 변화에 따른 걸음걸이 전환을 조절하는 신경회로적 분자적 기작 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000837686 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | Department of Brain Sciences | - |
| dc.identifier.bibliographicCitation | Kyeong Min Moon. (2025). Circuit mechanisms underlying gait switching in C. elegans. doi: 10.22677/THESIS.200000837686 | - |
| dc.contributor.coadvisor | Hyun-Ho Lim | - |
| dc.date.awarded | 2025-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BD 문14 202502 | - |
| dc.date.accepted | 2025-01-20 | - |
| dc.contributor.alternativeDepartment | 뇌과학과 | - |
| dc.subject.keyword | C. elegans, Gait transition, SMB neuron, unc-29, unc-79 | - |
| dc.contributor.affiliatedAuthor | Kyeong Min Moon | - |
| dc.contributor.affiliatedAuthor | Kyuhyung Kim | - |
| dc.contributor.affiliatedAuthor | Hyun-Ho Lim | - |
| dc.contributor.alternativeName | 문경민 | - |
| dc.contributor.alternativeName | Kyuhyung Kim | - |
| dc.contributor.alternativeName | 임현호 | - |
