Title

Circuit mechanisms underlying gait switching in C. elegans

Alternative Title

예쁜 꼬마 선충을 이용한 환경 변화에 따른 걸음걸이 전환을 조절하는 신경회로적 분자적 기작 연구

DGIST Authors

Kyeong Min Moon ; Kyuhyung Kim ; Hyun-Ho Lim

Advisor

김규형

Co-Advisor(s)

Hyun-Ho Lim

Issued Date

2025

Awarded Date

2025-02-01

Citation

Kyeong Min Moon. (2025). Circuit mechanisms underlying gait switching in C. elegans. doi: 10.22677/THESIS.200000837686

Type

Thesis

Description

C. elegans, Gait transition, SMB neuron, unc-29, unc-79

Table Of Contents

List of Contents
Abstract i
List of contents ii
List of tables iv
List of figures v

Ⅰ. INTRODUCTION
1.1 Locomotion in animals 1
1.2 Gait transition in animals 1
1.3 Locomotion in C. elegans 3
1.4 Gait transition in C. elegans 5
1.5 Summary 6
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
3.1 Characteristics of different types of locomotive strategies
in C. elegans 25
3.2 Gait transition is mediated by the head motor neuron SMB
and SMD 31
3.3 The SMB neurons control head muscle activity to restrict
head locomotion 42
3.4 Isolation of mutant strains that exhibit abnormal gait transition
and swimming behavior 47
3.5 NCA complex protein UNC-79 regulates gait transition and
swimming behavior 53
3.6 Acetylcholine receptor protein UNC-29 has a role in
gait transition and swimming behavior 64
3.7 Gait transition-induced calcium activity of body muscles is
mediated by nAChR 73
3.8 unc-29 may act downstream of SMB-mediated head muscle control
in gait transition and swimming 77
3.9 Candidate neurotransmitter in gait transition 79
3.10 Candidate sensory neurons in gait transition 79


Ⅳ. DISCUSSIONS
4.1 Crawling-to-Swimming transition is regulated by head motor
neurons: SMB and SMD 84
4.2 NCA channel subunit gene unc-79 regulates body locomotion to
mediate gait transition and sustenance of gaits. 85
4.3 nAChR subunit unc-29 gene in muscles regulates Ca2+ activity to
mediate proper gaits 86
4.4 Selecting gaits are regulated by complex neural circuit mechanisms
in C. elegans 87


Ⅴ. REFERENCES
Ⅵ. SUMMARY IN KOREANS
VII. APPENDIX
A FMRFamide-like neuropeptide FLP-12 signaling regulates head
locomotive behaviors in Caenorhabditis elegans 99

URI

http://hdl.handle.net/20.500.11750/57949
http://dgist.dcollection.net/common/orgView/200000837686

DOI

10.22677/THESIS.200000837686

Degree

Doctor

Department

Department of Brain Sciences

Publisher

DGIST

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