Cited 3 time in webofscience Cited 5 time in scopus

The Vomeronasal Organ and Adjacent Glands Express Components of Signaling Cascades Found in Sensory Neurons in the Main Olfactory System

Title
The Vomeronasal Organ and Adjacent Glands Express Components of Signaling Cascades Found in Sensory Neurons in the Main Olfactory System
Authors
Lee, Sang JinMammen, AlexKim, Esther JKim, So YeunPark, Yun JuPark, Mi RaHan, Hyung SooBae, Yong ChulRonnett, Gabriele VMoon, Che Il
DGIST Authors
Moon, Che Il
Issue Date
2008-11
Citation
Molecules and Cells, 26(5), 503-513
Type
Article
Article Type
Article
Keywords
glandimmunohistochemistryolfactionpheromonesignal transductionVNOvomeronasal
ISSN
1016-8478
Abstract
The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status. © 2008 KSMCB.
URI
http://hdl.handle.net/20.500.11750/5830
Publisher
한국분자세포생물학회
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


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