The present invention relates to an apparatus and a method for diagnosing a disease on the basis of artificial intelligence, wherein a disease can be diagnosed by using blood flow signals measured by means of an optical method, the apparatus comprising: a data preprocessing unit that generates input data required for artificial intelligence-based disease diagnosis by performing frequency analysis on received blood flow signal data; and an artificial intelligence-based disease diagnosis unit that diagnoses a disease by using the input data and an artificial intelligence model, wherein the input data includes relative magnitude data in a plurality of frequency bands associated with life phenomena for blood flow vibration data generated as a result of the frequency analysis on the blood flow signal data.
