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Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy

Title
Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy
Authors
Jung, EunkyeongKang, ChangsunLee, JeonghunYoo, DonghyuckHwang, Do WonKim, DohyunPark, Seong-CheolLim, Sang KyooSong, ChulgyuLee, Dongwon
DGIST Authors
Lim, Sang Kyoo
Issue Date
2018-01
Citation
Acs Nano, 12(1), 392-401
Type
Article
Article Type
Article
Keywords
HYDROGEN-PEROXIDEIN-VIVOULTRASOUNDMECHANISMSPLATELETSAGENT
ISSN
1936-0851
Abstract
A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an elevated level of hydrogen peroxide (H2O2), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H2O2-triggered photoacoustic signal amplification and serve as an antithrombotic nanomedicine. T-FBM nanoparticles were designed to target fibrin-rich thrombi and be activated by H2O2 to generate CO2 bubbles to amplify the photoacoustic signal. In the phantom studies, T-FBM nanoparticles showed significant amplification of ultrasound/photoacoustic signals in a H2O2-triggered manner. T-FBM nanoparticles also exerted H2O2-activatable antioxidant, anti-inflammatory, and antiplatelet activities on endothelial cells. In mouse models of carotid arterial injury, T-FBM nanoparticles significantly enhanced the photoacoustic contrast specifically in thrombosed vessels and significantly suppressed thrombus formation. We anticipate that T-FBM nanoparticles hold great translational potential as nanotheranostics for H2O2-associated cardiovascular diseases. © 2017 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/5882
DOI
10.1021/acsnano.7b06560
Publisher
American Chemical Society
Related Researcher
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Collection:
Smart Textile Convergence Research Group1. Journal Articles


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