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Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy

Title
Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy
Authors
Zheng, S.Han, J.Jin, Z.Kim, C.-S.Park, Suk HoKim, K.-P.Park, J.-O.Choi, E.
DGIST Authors
Park, Suk Ho
Issue Date
2018-04
Citation
Colloids and Surfaces B: Biointerfaces, 164, 424-435
Type
Article
Article Type
Article
Keywords
ChemotherapyControlled drug deliveryDiseasesDrug deliveryDrug productsFunctional polymersHyaluronic acidInfrared devicesIron oxidesMagnetic resonance imagingMagnetismMicellesMolecular biologyNanomagneticsNanoparticlesOrganic acidsPolymersSolutionsSynthesis (chemical)TumorsExternal magnetic fieldMagnetic nano-particlesPhoto-thermalPhotothermal ablationPhotothermal therapySuperparamagnetic iron oxide nanoparticlesSustained drug releaseTumor-targeted drug deliveriesTargeted drug delivery
ISSN
0927-7765
Abstract
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period. Moreover, the specific targeting capability based on CD44 recptor-mediated endocytosis and the enhanced targeting efficacy by in presence of external magnetic field were investigated. The clustered SPIONs within micelles exerted excellent contrast effect with high r2 relaxivity in MR phantom test. Furthermore, the multifunctional micelles could readily convert light to heat to hyperthermia temperature upon near infrared light irradition and induce photothermal ablation to breast cancer cells. The combined photothermal therapy with DTX-mediated chemotherapy of the developed multifunctional polymeric micells could generate a synergistic therapeutic effect. Based on these findings, the resulting multifunctional micelles may provide high potential for multimodality theragnosis of cancer. © 2018 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/5915
DOI
10.1016/j.colsurfb.2018.02.005
Publisher
Elsevier B.V.
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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