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Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy
- Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy
- Zheng, S.; Han, J.; Jin, Z.; Kim, C.-S.; Park, Suk Ho; Kim, K.-P.; Park, J.-O.; Choi, E.
- DGIST Authors
- Park, Suk Ho
- Issue Date
- Colloids and Surfaces B: Biointerfaces, 164, 424-435
- Article Type
- Chemotherapy; Controlled drug delivery; Diseases; Drug delivery; Drug products; Functional polymers; Hyaluronic acid; Infrared devices; Iron oxides; Magnetic resonance imaging; Magnetism; Micelles; Molecular biology; Nanomagnetics; Nanoparticles; Organic acids; Polymers; Solutions; Synthesis (chemical); Tumors; External magnetic field; Magnetic nano-particles; Photo-thermal; Photothermal ablation; Photothermal therapy; Superparamagnetic iron oxide nanoparticles; Sustained drug release; Tumor-targeted drug deliveries; Targeted drug delivery
- Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period. Moreover, the specific targeting capability based on CD44 recptor-mediated endocytosis and the enhanced targeting efficacy by in presence of external magnetic field were investigated. The clustered SPIONs within micelles exerted excellent contrast effect with high r2 relaxivity in MR phantom test. Furthermore, the multifunctional micelles could readily convert light to heat to hyperthermia temperature upon near infrared light irradition and induce photothermal ablation to breast cancer cells. The combined photothermal therapy with DTX-mediated chemotherapy of the developed multifunctional polymeric micells could generate a synergistic therapeutic effect. Based on these findings, the resulting multifunctional micelles may provide high potential for multimodality theragnosis of cancer. © 2018 Elsevier B.V.
- Elsevier B.V.
- Related Researcher
Multiscale Biomedical Robotics Laboratory
Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
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- Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles
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