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Maternal age shapes progeny neuronal function and behavior in C. elegans
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김규형 | - |
| dc.contributor.author | Hyeonjeong Hwang | - |
| dc.date.accessioned | 2026-01-23T10:53:49Z | - |
| dc.date.available | 2026-01-23T10:53:49Z | - |
| dc.date.issued | 2026 | - |
| dc.identifier.uri | https://scholar.dgist.ac.kr/handle/20.500.11750/59590 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000942574 | - |
| dc.description | maternal age, avoidance behavior, eri-1, microRNAs, neuropeptide, C. elegans, dispersal, transgenerational control | - |
| dc.description.tableofcontents | Ⅰ. INTRODUCTION 1 1.1 Lansing effects 1 1.2 Transgenerational inheritance 6 1.3 Small RNA pathway 8 1.4 Ascaroside signaling in C. elegans 12 1.5 Neuropeptide signaling in C. elegans 18 1.6 Summary 23 Ⅱ. MATERIALS AND METHODS 24 Ⅲ. RESULTS 36 3.1 Maternal age modulates progeny ascr#3 pheromone avoidance behavior in C. elegans 36 3.2 The exoribonuclease eri-1 mediates ascr#3 pheromone avoidance behavior 49 3.3 eri-1 is expressed in and acts in the AVH interneurons to regulate ascr#3 avoidance 60 3.4 The AVH neurons remotely control the activities of the ascr#3-sensing ADL neurons via FLP-26 neuropeptide signaling 68 3.5 ERI-1 downregulates the flp-26 mRNA level in the AVH neurons by regulating mir-8207 microRNA 80 3.6 Maternal age modulates eri-1–mir-8207–flp-26 signaling in the AVH neurons to shape ascr#3 avoidance 96 3.7 Maternal age determines dispersal potential of progeny 108 Ⅳ. DISCUSSIONS 111 4.1 Transgenerational regulation of ascr#3 avoidance behavior by maternal aging 112 4.2 ERI-1 as a molecular link between maternal provisioning and behavioral plasticity 113 4.3 AVH interneurons as a neural hub for maternal age-dependent behavioral plasticity 115 4.4 Evolutionary and ecological perspectives on ascr#3 behavioral plasticity across maternal age 116 Ⅴ. REFERENCES 119 Ⅵ. SUMMARY IN KOREANS 130 |
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| dc.format.extent | 131 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Maternal age shapes progeny neuronal function and behavior in C. elegans | - |
| dc.title.alternative | 예쁜 꼬마 선충의 모체 연령에 따른 자손 세대에서의 신경 기능과 행동 변화에 관한 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000942574 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | Department of Brain Sciences | - |
| dc.contributor.coadvisor | KyeongJin Kang | - |
| dc.date.awarded | 2026-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BD 황94 202602 | - |
| dc.date.accepted | 2026-01-19 | - |
| dc.contributor.alternativeDepartment | 뇌과학과 | - |
| dc.subject.keyword | maternal age, avoidance behavior, eri-1, microRNAs, neuropeptide, C. elegans, dispersal, transgenerational control | - |
| dc.contributor.affiliatedAuthor | Hyeonjeong Hwang | - |
| dc.contributor.affiliatedAuthor | Kyuhyung Kim | - |
| dc.contributor.affiliatedAuthor | KyeongJin Kang | - |
| dc.contributor.alternativeName | 황현정 | - |
| dc.contributor.alternativeName | Kyuhyung Kim | - |
| dc.contributor.alternativeName | 강경진 | - |
| dc.rights.embargoReleaseDate | 2027-02-28 | - |
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