Title

Maternal age shapes progeny neuronal function and behavior in C. elegans

Alternative Title

예쁜 꼬마 선충의 모체 연령에 따른 자손 세대에서의 신경 기능과 행동 변화에 관한 연구

DGIST Authors

Hyeonjeong Hwang ; Kyuhyung Kim ; KyeongJin Kang

Advisor

김규형

Co-Advisor(s)

KyeongJin Kang

Issued Date

2026

Awarded Date

2026-02-01

Type

Thesis

Description

maternal age, avoidance behavior, eri-1, microRNAs, neuropeptide, C. elegans, dispersal, transgenerational control

Table Of Contents

Ⅰ. INTRODUCTION 1
1.1 Lansing effects 1
1.2 Transgenerational inheritance 6
1.3 Small RNA pathway 8
1.4 Ascaroside signaling in C. elegans 12
1.5 Neuropeptide signaling in C. elegans 18
1.6 Summary 23
Ⅱ. MATERIALS AND METHODS 24
Ⅲ. RESULTS 36
3.1 Maternal age modulates progeny ascr#3 pheromone avoidance behavior in C. elegans 36
3.2 The exoribonuclease eri-1 mediates ascr#3 pheromone avoidance behavior 49
3.3 eri-1 is expressed in and acts in the AVH interneurons to regulate ascr#3 avoidance 60
3.4 The AVH neurons remotely control the activities of the ascr#3-sensing ADL neurons via FLP-26 neuropeptide signaling 68
3.5 ERI-1 downregulates the flp-26 mRNA level in the AVH neurons by regulating mir-8207 microRNA 80
3.6 Maternal age modulates eri-1–mir-8207–flp-26 signaling in the AVH neurons to shape ascr#3 avoidance 96
3.7 Maternal age determines dispersal potential of progeny 108
Ⅳ. DISCUSSIONS 111
4.1 Transgenerational regulation of ascr#3 avoidance behavior by maternal aging 112
4.2 ERI-1 as a molecular link between maternal provisioning and behavioral plasticity 113
4.3 AVH interneurons as a neural hub for maternal age-dependent behavioral plasticity 115
4.4 Evolutionary and ecological perspectives on ascr#3 behavioral plasticity across maternal age 116
Ⅴ. REFERENCES 119
Ⅵ. SUMMARY IN KOREANS 130

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59590
http://dgist.dcollection.net/common/orgView/200000942574

DOI

10.22677/THESIS.200000942574

Degree

Doctor

Department

Department of Brain Sciences

Publisher

DGIST

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