Title

Development of peripheral nerve interface for long-term recording of sensory receptor activity

DGIST Authors

Byung Wook Park ; Sohee Kim

Advisor

김소희

Issued Date

2026

Awarded Date

2026-02-01

Type

Thesis

Description

Neural interface, peripheral nerve interface, intraneural interface, peripheral nerve recording, intraneural recording, somatosensory neural recording, flexible electrode, ultraflexible electrode

Table Of Contents

Chapter Ⅰ Introduction 1
1.1 Overview of peripheral nerve and peripheral nerve interface 2
1.2 Current challenge of sensory feedback & peripheral neve interface 4
1.3 Trends in Peripheral nerve interface research for nerve recording 5
1.4 Goal of this research 10
Chapter ⅠⅠ Development of an intraneural mesh interface for long-term tracking of sensory receptor activity 11
2.1 Introduction 12
2.2 Methods 13
2.2.1 Fabrication 13
2.2.2 Surgery & Implantation 16
2.2.3 Peripheral nerve signal acquisition and spike sorting & processing 20
2.3. Results 22
2.3.1 Fabricated FPMA system & electrical characterization 22
2.3.2 axon-level peripheral nerve recording 23
2.3.3 Axon-level recording and modeling of somatosensory activity from multiple origins 24
2.3.4 Multichannel recording of somatosensory signals from the peripheral nerve 32
2.3.5 Neural recording of tactile ensemble activity from multiple mechanoreceptor origins 35
2.3.6 Neural recording of proprioceptive ensemble activity from multiple MS axons 36
2.3.7 Long-term axon-level tracking of proprioceptive signals using the FPMA system 39
Chapter Ⅲ Development of an intraneural mesh interface for long-term tracking of sensory receptor activity 48
3.1 Introduction 49
3.2 Methods 52
3.2.1 Fabrication 52
3.2.2 Carrier fabrication & integration 54
3.2.3 Surgery & Implantation 54
3.2.4 Peripheral nerve signal acquisition and spike sorting & processing 56
3.2.5 Immunohistochemistry and histology analysis 57
3.2.6 Footprint analysis 61
3.3. Results 62
3.3.1 Fabricated intraneural Mesh interface 62
3.3.2 Recording configuration & axon-level peripheral nerve recording 63
3.3.3 Long-term axon-level tracking of proprioceptive signals using the intraneural mesh interface 66
3.3.4 Evaluation of scar tissue formation and neural tissue regeneration according to intraneural interface shape 72
3.3.5 Evaluation of foreign body response according to intraneural interface shape 79
3.3.6 Functional recovery assessment based on footprint analysis 82
Chapter Ⅳ Discussion and Future plan 85
4.1 Discussion 86
4.2 Future plan 91
References 93
요약문 100

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59610
http://dgist.dcollection.net/common/orgView/200000947487

DOI

10.22677/THESIS.200000947487

Degree

Doctor

Department

Department of Robotics and Mechatronics Engineering

Publisher

DGIST

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