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Regulation of KCNQ Channel Gating Properties by CaBP1
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 서병창 | - |
| dc.contributor.author | Byoungheon Kang | - |
| dc.date.accessioned | 2026-01-23T10:54:43Z | - |
| dc.date.available | 2026-01-23T10:54:43Z | - |
| dc.date.issued | 2026 | - |
| dc.identifier.uri | https://scholar.dgist.ac.kr/handle/20.500.11750/59648 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000947520 | - |
| dc.description | CaBP1, CaM, KCNQ, PIP2, Myristoylation | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 II. MATERIALS AND METHODS 3 2.1 Cell culture and Transfection 3 2.2 Confocal microscopy 3 2.3 Cell lysis and Co-immunoprecipitation 3 2.4 Western blotting 4 2.5 Electrophysiological recording 4 2.6 Statistical Analysis 5 III. RESULTS 6 3.1 CaBP1 Distinctly Modulates KCNQ2/3 Current Density in Opposition to CaM 6 3.2 Voltage dependence of activation on KCNQ channel with CaM or CaBP1 6 3.3 CaBP1 Accelerates the Activation and Deactivation Kinetics of KCNQ2/3 7 3.4 N-terminal Myristoylation is the Determinant for CaBP1 Membrane Targeting 10 3.5 Membrane Localization is Prerequisite for CaBP1-Mediated Channel Regulation 10 3.6 Differential regulation of PIP2 sensitivity of KCNQ2/3 by CaBP1 vs CaM 13 3.7 CaBP1 Buffers Channel Inhibition Mediated by Physiological Gq-Protein Signaling 13 3.8 Only membrane-localized CaBP1 alters the apparent PIP₂ sensitivity of KCNQ2/3 16 3.9 CaBP1 is expressed as multiple variants across brain regions and physically associated with KCNQ2 16 3.10 Model: CaBP1 preserves KCNQ2/3 opening during partial–but not complete—PIP2 depletion at the S4-S5 linker 19 ⅠV. DISCUSSION 21 V. REFERENCES 24 VI. SUMMARY IN KOREAN 27 |
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| dc.format.extent | 28 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Regulation of KCNQ Channel Gating Properties by CaBP1 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000947520 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of Brain Sciences | - |
| dc.contributor.coadvisor | Myungin Baek | - |
| dc.date.awarded | 2026-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 강44 202602 | - |
| dc.date.accepted | 2026-01-19 | - |
| dc.contributor.alternativeDepartment | 뇌과학과 | - |
| dc.subject.keyword | CaBP1, CaM, KCNQ, PIP2, Myristoylation | - |
| dc.contributor.affiliatedAuthor | Byoungheon Kang | - |
| dc.contributor.affiliatedAuthor | Byung-Chang Suh | - |
| dc.contributor.affiliatedAuthor | Myungin Baek | - |
| dc.contributor.alternativeName | 강병헌 | - |
| dc.contributor.alternativeName | Byung-Chang Suh | - |
| dc.contributor.alternativeName | 백명인 | - |
| dc.rights.embargoReleaseDate | 2030-08-31 | - |
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