Title

Synthesis of CF₂H-Substituted Alkanes via NiH-Catalyzed Hydroalkylation of Unactivated Alkenes

Alternative Title

니켈 하이드라이드 촉매하에서 비활성 알켄의 하이드로알킬화 반응을 통한 디플루오로메틸 치환 알케인 합성

DGIST Authors

Gyuhwan Sim ; Sangwon Seo

Advisor

서상원

Issued Date

2026

Awarded Date

2026-02-01

Type

Thesis

Description

Difluoromethylation, Ni-catalysis, Cross-coupling reaction, C(sp³)–CF₂H bond formation, Regioselective functionalization

Table Of Contents

Ⅰ. Introduction 1
1.1 Backgrounds 1
1.2 Previous studies 2
1.3 Our work 4
II. RESULTS AND DISCUSSIONS 6
2.1 Optimization of reaction conditions 6
2.2 Substrate scopes 12
2.2.1 Substrate scopes of Olefins 12
2.2.2 Substrate scopes of Alkyl halide 13
2.3 Asymmetric reaction 14
2.4 Future work 15
III. CONCLUSION 17
IV. EXPERIMENTAL SECTION 18
REFERENCE 29
국문 요약문 31

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59743
http://dgist.dcollection.net/common/orgView/200000942916

DOI

10.22677/THESIS.200000942916

Degree

Master

Department

Department of Physics and Chemistry

Publisher

DGIST

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