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  Department of Brain Sciences Theses Master

The EGFR and VEGFR2 inhibitor vandetanib alleviates neuroinflammation and pyroptosis through NLRP3/SOD2 and JNK/NF-kB signaling in LPS-treated wild-type mice

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dc.contributor.advisor 현정호 -
dc.contributor.author Ji-Yeong Jang -
dc.date.accessioned 2026-01-23T11:01:06Z -
dc.date.available 2026-01-23T11:01:06Z -
dc.date.issued 2025 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/59809 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000893745 -
dc.description Vandetanib, EGFR, VEGFR, neuroinflammation, NLRP3, JNK -
dc.description.tableofcontents List of Contents

Abstract i
List of contents ii


Ⅰ. Introduction

II. Materials and Methods
2.1 Vandetanib 3
2.2 Cell culture 3
2.3 Cytotoxicity assays 3
2.4 Wild-type mice 3
2.5 Real-time quantitative PCR 4
2.6 Nuclear fractionation 6
2.7 Western blotting 6
2.8 Immunofluorescence staining 8
2.9 Statistical analysis 9
.
III. Results
3.1 Vandetanib treatment reduces LPS-induced proinflammatory cytokine expression in BV2 microglial cells by decreasing NLRP3/SOD2 expression and JNK/NF-kB phosphorylation 10
3.2 Vandetanib suppresses proinflammatory cytokine and NLRP3/SOD2 expression and NF-kB phosphorylation in LPS-treated primary astrocytes 12
3.3 Vandetanib alleviates microgliosis and astrogliosis in LPS-treated wild-type mice 13
3.4 Vandetanib decreases LPS-evoked proinflammatory cytokine expression in wild-type mice 16
3.5 Vandetanib suppresses the expression of the neuroinflammation-associated molecular targets NLRP3 and SOD2 in LPS-treated wild-type mice 20
3.6 Vandetanib reduces LPS-mediated microglial and astroglial neuroinflammatory dynamics in WT mice 22
3.7 Vandetanib diminishes LPS-stimulated JNK/NF-kB phosphorylation in wild-type mice 23
3.8 Vandetanib alleviates LPS-mediated pyroptosis in wild-type mice 25

IV. Discussion

V. Conclusions		 -
dc.format.extent 39 -
dc.language eng -
dc.publisher DGIST -
dc.title The EGFR and VEGFR2 inhibitor vandetanib alleviates neuroinflammation and pyroptosis through NLRP3/SOD2 and JNK/NF-kB signaling in LPS-treated wild-type mice -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200000893745 -
dc.description.degree Master -
dc.contributor.department Department of Brain Sciences -
dc.contributor.coadvisor Hyang-Sook Hoe -
dc.date.awarded 2025-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 장78 202508 -
dc.date.accepted 2025-07-21 -
dc.contributor.alternativeDepartment 뇌과학과 -
dc.subject.keyword Vandetanib, EGFR, VEGFR, neuroinflammation, NLRP3, JNK -
dc.contributor.affiliatedAuthor Ji-Yeong Jang -
dc.contributor.affiliatedAuthor Jung Ho Hyun -
dc.contributor.affiliatedAuthor Hyang-Sook Hoe -
dc.contributor.alternativeName 장지영 -
dc.contributor.alternativeName Jung Ho Hyun -
dc.contributor.alternativeName 허향숙 -
dc.rights.embargoReleaseDate 2027-08-31 -
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