손 떨림 보정 및 광학 거리 제어를 이용한 비접촉 휴대형 공초점 망막 내시현미경 시스템

Abstract

We present a novel handheld confocal endomicroscopy system designed for non-contact, high-resolution retinal imaging, integrating motorized stabilization and tremor prediction. The system combines a custom PZT-driven Lissajous scanning probe, and a common-path swept-source optical coherence tomography (CPSS-OCT) sensor for depth tracking for real-time tremor compensation. This multimodal platform allows continuous imaging at the cellular level without requiring probe-to-tissue contact, addressing critical limitations of conventional probe-based confocal laser endomicroscopy(pCLE) systems. Experimental evaluations using ex-vivo bovine retina samples demonstrated significant enhancements in image clarity, with the CR score increasing by 48.43% under active tremor control. The proposed architecture offers improved image stability, precise axial focusing, and handheld portability, making it a strong candidate for clinical applications in retinal diagnostics and intraoperative imaging.