Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation

Abstract

Magnetoelectric materials, which generate electric fields in response to alternating magnetic stimulation, are increasingly recognized for their applications in neuromodulation, tissue engineering, wireless drug delivery, and cancer treatment. This study addresses the cytotoxicity concerns associated with heavy metals in traditional magnetoelectric composites by introducing a heat-mediated magnetoelectric approach utilizing biocompatible iron oxide nanoparticles and pyroelectric polymers, thereby enhancing biomedical safety. The nanoparticles were synthesized with controlled size and shape via thermal decomposition of iron oleate, employing an in situ temperature labeling technique that simplifies the synthesis process and ensures uniform particle formation. These nanoparticles, optimized for high heating efficiency, were combined with the pyroelectric polymer P(VDF-TrFE) to create composite films that exhibit a heat-mediated magnetoelectric effect. This effect involves an alternating magnetic field heating the nanoparticles, leading to reversible material depolarization and the generation of a pyroelectric current. We explored the magnetopyroelectric effect on cell differentiation, demonstrating excellent biocompatibility with neural progenitor cells and significant enhancement in neuronal differentiation, attributed to the synergistic effects of heat and electricity. The pro-differentiation mechanism of magnetopyroelectric stimulation involves phosphatidylinositol 3 kinase AKT pathway and calcium signaling. This heat-mediated magnetoelectric approach not only presents a potential for applications such as neuronal repair and targeted drug delivery but also provides a safer and more versatile alternative to conventional magnetoelectric materials.