Department of Physics and Chemistry
Asymmetric Organic Synthesis and Drug Synthesis Laboratory
1. Journal Articles
Direct synthesis of anthracenes from o-tolualdehydes and aryl iodides through Pd(II)-Catalyzed sp3 CH arylation and electrophilic aromatic cyclization
- Title
- Direct synthesis of anthracenes from o-tolualdehydes and aryl iodides through Pd(II)-Catalyzed sp3 CH arylation and electrophilic aromatic cyclization
- Author(s)
- Park, H. ; Yoo, K. ; Jung, Byung Hyuck ; Kim, M.
- Issued Date
- 2018-04
- Citation
- Tetrahedron, v.74, no.16, pp.2048 - 2055
- Type
- Article
- Author Keywords
- Transient directing groups ; C-H activation ; sp(3) C-H arylation ; One-pot synthesis ; Anthracenes
- Keywords
- METAL-ORGANIC FRAMEWORK ; BOND ACTIVATION ; ATOM ECONOMY ; C(SP(3))-H ARYLATION ; ALIPHATIC-KETONES ; NATURAL-PRODUCTS ; FUNCTIONALIZATION ; CONSTRUCTION ; DERIVATIVES ; CATALYSIS
- ISSN
- 0040-4020
- Abstract
- The first direct synthesis of substituted anthracenes from o-tolualdehydes and aryl iodides via a Pd(II)-catalyzed C. H arylation using an alcohol-bearing transient directing group and subsequent AgOTf-assisted electrophilic aromatic cyclization is described. New transient directing groups consisting of amino acids and amino alcohols enhanced the reactivity, and the C. H arylation was complete in 12 h at 90 °C. By simply changing the silver salt to silver triflate, the one-pot synthesis of anthracene derivatives was carried out using the present reaction conditions. © 2018 Elsevier Ltd.
- Publisher
- Elsevier Ltd
- Related Researcher
-
-
Jung, Byunghyuck
- Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
-
- Files in This Item:
-
There are no files associated with this item.
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.