Synapse development organized by neuronal activity-regulated immediate-early genes
- Title
- Synapse development organized by neuronal activity-regulated immediate-early genes
- Author(s)
- Kim, Seung Jun ; Kim, Hyeon Ho ; Um, Ji Won
- Issued Date
- 2018-04
- Citation
- Experimental and Molecular Medicine, v.50, no.4, pp.1 - 7
- Type
- Article
- Keywords
- LONG-TERM POTENTIATION ; METABOTROPIC GLUTAMATE RECEPTORS ; TRANSCRANIAL MAGNETIC STIMULATION ; CYTOSKELETON-ASSOCIATED PROTEIN ; ACTIVITY-DEPENDENT REGULATION ; PRIMARY VISUAL-CORTEX ; FRAGILE-X-SYNDROME ; MESSENGER-RNA ; HOMEOSTATIC PLASTICITY ; HIPPOCAMPAL-NEURONS
- ISSN
- 1226-3613
- Abstract
- Classical studies have shown that neuronal immediate-early genes (IEGs) play important roles in synaptic processes critical for key brain functions. IEGs are transiently activated and rapidly upregulated in discrete neurons in response to a wide variety of cellular stimuli, and they are uniquely involved in various aspects of synapse development. In this review, we summarize recent studies of a subset of neuronal IEGs in regulating synapse formation, transmission, and plasticity. We also discuss how the dysregulation of neuronal IEGs is associated with the onset of various brain disorders and pinpoint key outstanding questions that should be addressed in this field. © 2018 The Author(s).
- Publisher
- Nature Publishing Group
- Related Researcher
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Um, Ji Won
- Research Interests Molecular and cellular mechanisms underlying synapse elimination; Key synaptic mechanisms associated with Alzheimer's disease and autism spectrum disorders; Synaptic homeostasis
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- Files in This Item:
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- Appears in Collections:
- Department of Brain Sciences Synapse Disorder Laboratory 1. Journal Articles
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