Cited 17 time in webofscience Cited 20 time in scopus

Synapse development organized by neuronal activity-regulated immediate-early genes

Title
Synapse development organized by neuronal activity-regulated immediate-early genes
Authors
Kim, Seung JunKim, Hyeon HoUm, Ji Won
DGIST Authors
Kim, Seung Jun; Kim, Hyeon Ho; Um, Ji Won
Issue Date
2018-04
Citation
Experimental and Molecular Medicine, 50(4), 1-7
Type
Article
Article Type
Review
Keywords
LONG-TERM POTENTIATIONMETABOTROPIC GLUTAMATE RECEPTORSTRANSCRANIAL MAGNETIC STIMULATIONCYTOSKELETON-ASSOCIATED PROTEINACTIVITY-DEPENDENT REGULATIONPRIMARY VISUAL-CORTEXFRAGILE-X-SYNDROMEMESSENGER-RNAHOMEOSTATIC PLASTICITYHIPPOCAMPAL-NEURONS
ISSN
1226-3613
Abstract
Classical studies have shown that neuronal immediate-early genes (IEGs) play important roles in synaptic processes critical for key brain functions. IEGs are transiently activated and rapidly upregulated in discrete neurons in response to a wide variety of cellular stimuli, and they are uniquely involved in various aspects of synapse development. In this review, we summarize recent studies of a subset of neuronal IEGs in regulating synapse formation, transmission, and plasticity. We also discuss how the dysregulation of neuronal IEGs is associated with the onset of various brain disorders and pinpoint key outstanding questions that should be addressed in this field. © 2018 The Author(s).
URI
http://hdl.handle.net/20.500.11750/6255
DOI
10.1038/s12276-018-0025-1
Publisher
Nature Publishing Group
Related Researcher
  • Author Um, Ji Won Synapse Disorder Laboratory
  • Research Interests Molecular and cellular mechanisms underlying synapse elimination; Key synaptic mechanisms associated with Alzheimer's disease and autism spectrum disorders; Synaptic homeostasis
Files:
Collection:
Department of Brain and Cognitive SciencesSynapse Disorder Laboratory1. Journal Articles


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