Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Leem, Eunju | - |
dc.contributor.author | Kim, Hyung-Jun | - |
dc.contributor.author | Choi, Minji | - |
dc.contributor.author | Kim, Sehwan | - |
dc.contributor.author | Oh, Yong Seok | - |
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Choe, Young-Shik | - |
dc.contributor.author | Um, Jae-Young | - |
dc.contributor.author | Shin, Won-Ho | - |
dc.contributor.author | Jeong, Jae Yeong | - |
dc.contributor.author | Jin, Byung Kwan | - |
dc.contributor.author | Kim, Dong Woon | - |
dc.contributor.author | McLean, Catriona | - |
dc.contributor.author | Fisher, Paul B | - |
dc.contributor.author | Kholodilov, Nikolai | - |
dc.contributor.author | Ahn, Kwang Seok | - |
dc.contributor.author | Lee, Jae Man | - |
dc.contributor.author | Jung, Un Ju | - |
dc.contributor.author | Lee, Seok-Geun | - |
dc.contributor.author | Kim, Sang Ryong | - |
dc.date.accessioned | 2018-05-06T03:54:02Z | - |
dc.date.available | 2018-05-06T03:54:02Z | - |
dc.date.created | 2018-05-04 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Cell Death and Disease, v.9, no.5 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6293 | - |
dc.description.abstract | The role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the postmortem substantia nigra of patients with Parkinson's disease (PD) compared to age-matched controls. Similarly, decreased AEG-1 levels were found in the 6-hydroxydopamine (6-OHDA) mouse model of PD. An adeno-associated virus-induced increase in the expression of AEG-1 attenuated the 6-OHDA-triggered apoptotic death of nigral DA neurons. Moreover, the neuroprotection conferred by the AEG-1 upregulation significantly intensified the neurorestorative effects of the constitutively active ras homolog enriched in the brain [Rheb(S16H)]. Collectively, these results demonstrated that the sustained level of AEG-1 as an important anti-apoptotic factor in nigral DA neurons might potentiate the therapeutic effects of treatments, such as Rheb(S16H) administration, on the degeneration of the DA pathway that characterizes PD. © 2018 The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41419-018-0491-3 | - |
dc.identifier.wosid | 000431779800011 | - |
dc.identifier.scopusid | 2-s2.0-85045767128 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Cell Death and Disease | - |
dc.contributor.nonIdAuthor | Leem, Eunju | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Jun | - |
dc.contributor.nonIdAuthor | Choi, Minji | - |
dc.contributor.nonIdAuthor | Kim, Sehwan | - |
dc.contributor.nonIdAuthor | Lee, Kea Joo | - |
dc.contributor.nonIdAuthor | Choe, Young-Shik | - |
dc.contributor.nonIdAuthor | Um, Jae-Young | - |
dc.contributor.nonIdAuthor | Shin, Won-Ho | - |
dc.contributor.nonIdAuthor | Jeong, Jae Yeong | - |
dc.contributor.nonIdAuthor | Jin, Byung Kwan | - |
dc.contributor.nonIdAuthor | Kim, Dong Woon | - |
dc.contributor.nonIdAuthor | McLean, Catriona | - |
dc.contributor.nonIdAuthor | Fisher, Paul B | - |
dc.contributor.nonIdAuthor | Kholodilov, Nikolai | - |
dc.contributor.nonIdAuthor | Ahn, Kwang Seok | - |
dc.contributor.nonIdAuthor | Lee, Jae Man | - |
dc.contributor.nonIdAuthor | Jung, Un Ju | - |
dc.contributor.nonIdAuthor | Lee, Seok-Geun | - |
dc.contributor.nonIdAuthor | Kim, Sang Ryong | - |
dc.identifier.citationVolume | 9 | - |
dc.identifier.citationNumber | 5 | - |
dc.identifier.citationTitle | Cell Death and Disease | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | RAPID SUBTRACTION HYBRIDIZATION | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE MODELS | - |
dc.subject.keywordPlus | PKC-DELTA | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.contributor.affiliatedAuthor | Leem, Eunju | - |
dc.contributor.affiliatedAuthor | Kim, Hyung-Jun | - |
dc.contributor.affiliatedAuthor | Choi, Minji | - |
dc.contributor.affiliatedAuthor | Kim, Sehwan | - |
dc.contributor.affiliatedAuthor | Oh, Yong Seok | - |
dc.contributor.affiliatedAuthor | Lee, Kea Joo | - |
dc.contributor.affiliatedAuthor | Choe, Young-Shik | - |
dc.contributor.affiliatedAuthor | Um, Jae-Young | - |
dc.contributor.affiliatedAuthor | Shin, Won-Ho | - |
dc.contributor.affiliatedAuthor | Jeong, Jae Yeong | - |
dc.contributor.affiliatedAuthor | Jin, Byung Kwan | - |
dc.contributor.affiliatedAuthor | Kim, Dong Woon | - |
dc.contributor.affiliatedAuthor | McLean, Catriona | - |
dc.contributor.affiliatedAuthor | Fisher, Paul B | - |
dc.contributor.affiliatedAuthor | Kholodilov, Nikolai | - |
dc.contributor.affiliatedAuthor | Ahn, Kwang Seok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Man | - |
dc.contributor.affiliatedAuthor | Jung, Un Ju | - |
dc.contributor.affiliatedAuthor | Lee, Seok-Geun | - |
dc.contributor.affiliatedAuthor | Kim, Sang Ryong | - |