Cited 3 time in webofscience Cited 4 time in scopus

Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery

Title
Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery
Authors
Hu, XinghaoLim, Byeong HwaRamulu, Torati SriDing, JunjiaNovosad, ValentineIm, Mi‐YoungVenu, ReddyKim, Kun WooJung, Eun JooShawl, Asif IqbalKim, EunjooKim, CheolGi
DGIST Authors
Ramulu, Torati Sri; Kim, EunjooKim, CheolGi
Issue Date
2018-06
Citation
Small, 14(25), 1800504
Type
Article
Article Type
Article
Keywords
BiochipsDigital microfluidicsLab-on-a-chipMagnetsBiofunctionalizationDigital manipulationDonor and acceptorHigh resolutionMagnetic microrobotsMicro-particlesMicrorobotsOn-chip separationsBiomolecules
ISSN
1613-6810
Abstract
The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. Here, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI
http://hdl.handle.net/20.500.11750/6411
DOI
10.1002/smll.201800504
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Kim, CheolGi Lab for NanoBio-MatErials & SpinTronics(nBEST)
  • Research Interests Magnetic Materials and Spintronics; Converging Technology of Nanomaterials and Biomaterials; Bio-NEMS;MEMS
Files:
There are no files associated with this item.
Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles
Department of Emerging Materials ScienceETC1. Journal Articles
Department of Emerging Materials ScienceLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles


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