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Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
- Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
- Yang, Katherine S.; Im, Hyungsoon; Hong, Seonki; Pergolini, Ilari; del Castillo; Wang, Rui; Clardy, Susan; Huang, Chen-Han; Pille, Craig; Ferrone, Soldano; Yang, Robert; Castro, Cesar M.; Lee, Hakho; del Castillo; Weissleder, Ral
- DGIST Authors
- Hong, Seonki
- Issue Date
- SCIENCE TRANSLATIONAL MEDICINE, 9(391)
- Article Type
- ANTIBODY-BASED IMMUNOTHERAPY; CIRCULATING TUMOR-CELLS; EXTRACELLULAR VESICLES; CANCER-DIAGNOSIS; BIOMARKERS; EXOSOMES; GLYPICAN-1; MARKERS; PROTEIN; GLIOBLASTOMA
- Pancreatic ductal adenocarcinoma (PDAC) is usually detected late in the disease process. Clinical workup through imaging and tissue biopsies is often complex and expensive due to a paucity of reliable biomarkers. We used an advanced multiplexed plasmonic assay to analyze circulating tumor-derived extracellular vesicles (tEVs) in more than 100 clinical populations. Using EV-based protein marker profiling, we identified a signature of five markers (PDACEV signature) for PDAC detection. In our prospective cohort, the accuracy for the PDACEV signature was 84% [95% confidence interval (CI), 69 to 93%] but only 63 to 72% for single-marker screening. One of the best markers, GPC1 alone, had a sensitivity of 82% (CI, 60 to 95%) and a specificity of 52% (CI, 30 to 74%), whereas the PDACEV signature showed a sensitivity of 86% (CI, 65 to 97%) and a specificity of 81% (CI, 58 to 95%). The PDACEV signature of tEVs offered higher sensitivity, specificity, and accuracy than the existing serum marker (CA 19-9) or single-tEV marker analyses. This approach should improve the diagnosis of pancreatic cancer. © The Authors, some rights reserved;.
- AMER ASSOC ADVANCEMENT SCIENCE
- Related Researcher
Biomaterials & Biointerface Engineering Laboratory
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- Department of Emerging Materials ScienceBiomaterials & Biointerface Engineering Laboratory1. Journal Articles
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