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One-step optogenetics with multifunctional flexible polymer fibers
- One-step optogenetics with multifunctional flexible polymer fibers
- Park, Seongjun; Guo, Yuanyuan; Jia, Xiaoting; Choe, Han Kyoung; Grena, Benjamin; Kang, Jeewoo; Park, Jiyeon; Lu, Chi; Canales, Andres; Chen, Ritchie; Yim, Yeong Shin; Choi, Gloria B.; Fink, Yoel; Anikeeva, Polina
- DGIST Authors
- Choe, Han Kyoung
- Issue Date
- NATURE NEUROSCIENCE, 20(4), 612-+
- Article Type
- IN-VIVO; CONDUCTING POLYMERS; NEURAL INTERFACES; SOCIAL-BEHAVIOR; NEURONS; TISSUE; CHANNELRHODOPSIN-2; INTERROGATION; DISEASE; SYSTEMS
- Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (<200 μm) footprint and modest weight (<0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
- NATURE PUBLISHING GROUP
- Related Researcher
Choe, Han Kyoung
Laboratory of Animal Behavior and Circadian rhythm
Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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- Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles
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