Cited 149 time in webofscience Cited 151 time in scopus

One-step optogenetics with multifunctional flexible polymer fibers

Title
One-step optogenetics with multifunctional flexible polymer fibers
Authors
Park, SeongjunGuo, YuanyuanJia, XiaotingChoe, Han KyoungGrena, BenjaminKang, JeewooPark, JiyeonLu, ChiCanales, AndresChen, RitchieYim, Yeong ShinChoi, Gloria B.Fink, YoelAnikeeva, Polina
DGIST Authors
Choe, Han Kyoung
Issue Date
2017-04
Citation
NATURE NEUROSCIENCE, 20(4), 612-+
Type
Article
Article Type
Article
Keywords
IN-VIVOCONDUCTING POLYMERSNEURAL INTERFACESSOCIAL-BEHAVIORNEURONSTISSUECHANNELRHODOPSIN-2INTERROGATIONDISEASESYSTEMS
ISSN
1097-6256
Abstract
Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (<200 μm) footprint and modest weight (<0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/6535
DOI
10.1038/nn.4510
Publisher
NATURE PUBLISHING GROUP
Related Researcher
  • Author Choe, Han Kyoung Laboratory of Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles


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