Cited 42 time in webofscience Cited 43 time in scopus

Time- evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis

Title
Time- evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis
Authors
Kim, Hyo JungPark, Ji-HwanKim, JingilKim, Jung JuHong, SunghyunKim, JeongsikKim, Jin HeeWoo, Hye RyunHyeon, ChangbongLim, Pyung OkNam, Hong GilHwang, Dae Hee
DGIST Authors
Woo, Hye RyunLim, Pyung OkNam, Hong Gil; Hwang, Dae Hee
Issue Date
2018-05
Citation
Proceedings of the National Academy of Sciences of the United States of America, 115(21), E4930-E4939
Type
Article
Article Type
Article
Keywords
TRANSCRIPTION FACTOR FAMILYSALICYLIC-ACIDTHALIANAEXPRESSIONSTRESSIDENTIFICATIONSPECIFICITYLONGEVITYPLANTSMEMBER
ISSN
0027-8424
Abstract
Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks was a shift from positive to negative regulation among NACs at a presenescent stage. ANAC017, ANAC082, and ANAC090, referred to as a “NAC troika,” govern the positive-to-negative regulatory shift. Knockout of the NAC troika accelerated senescence and the induction of other NACs, whereas overexpression of the NAC troika had the opposite effects. Transcriptome and molecular analyses revealed shared suppression of senescence-promoting processes by the NAC troika, including salicylic acid (SA) and reactive oxygen species (ROS) responses, but with predominant regulation of SA and ROS responses by ANAC090 and ANAC017, respectively. Our time-evolving networks provide a unique regulatory module of presenescent repressors that direct the timely induction of senescence-promoting processes at the presenescent stage of leaf aging. © 2018 National Academy of Sciences. All Rights Reserved.
URI
http://hdl.handle.net/20.500.11750/6582
DOI
10.1073/pnas.1721523115
Publisher
National Academy of Sciences
Related Researcher
  • Author Lim, Pyung Ok Plant Senescence Laboratory
  • Research Interests Aging and programmen cell death in plants; RNA-based regulation of leaf aging; Synthetic genetics-based aging reprogramming
Files:
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Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
Department of New BiologySystems Biology and Medicine Lab1. Journal Articles


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