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An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

Title
An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases
Authors
Bhandary, BidurMarahatta, AnuKim, Hyung-RyongChae, Han-Jung
DGIST Authors
Kim, Hyung-Ryong
Issue Date
2013-01
Citation
International Journal of Molecular Sciences, 14(1), 434-456
Type
Article
Article Type
Review
Keywords
ER stressER stress associated diseaseER associated oxidative stressdisulfide bond formationPDIERO-1 alphamitochondria electron transport chainUNFOLDED PROTEIN RESPONSEPERMEABILITY TRANSITION POREPANCREATIC BETA-CELLSNECROSIS-FACTOR-ALPHANF-KAPPA-BER STRESSALZHEIMERS-DISEASENITRIC-OXIDEMACULAR DEGENERATIONMITOCHONDRIAL RESPIRATION
ISSN
1422-0067
Abstract
The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress.© 2013 by the authors; licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/6614
DOI
10.3390/ijms14010434
Publisher
MDPI AG
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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