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An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

Title
An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases
Authors
Bhandary, BidurMarahatta, AnuKim, Hyung-RyongChae, Han-Jung
DGIST Authors
Kim, Hyung-Ryong
Issue Date
2013-01
Citation
International Journal of Molecular Sciences, 14(1), 434-456
Type
Article
Article Type
Review
ISSN
1661-6596
Abstract
The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress.© 2013 by the authors; licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/6614
DOI
10.3390/ijms14010434
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Files:
Collection:
ETC1. Journal Articles


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