Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bucher, Felicitas | - |
dc.contributor.author | Lee, Jungho | - |
dc.contributor.author | Shin, Sanghee | - |
dc.contributor.author | Kim, Minseok S. | - |
dc.contributor.author | Oh, Yong-Seok | - |
dc.contributor.author | Ha, Sanghoon | - |
dc.contributor.author | Zhang, Hongkai | - |
dc.contributor.author | Yea, Kyungmoo | - |
dc.date.accessioned | 2018-07-11T11:22:53Z | - |
dc.date.available | 2018-07-11T11:22:53Z | - |
dc.date.created | 2018-07-06 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | Cytokine, v.110, pp.397 - 403 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6663 | - |
dc.description.abstract | Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation. © 2018 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.title | Interleukin-5 suppresses Vascular Endothelial Growth Factor-induced angiogenesis through STAT5 signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cyto.2018.06.021 | - |
dc.identifier.wosid | 000443666100056 | - |
dc.identifier.scopusid | 2-s2.0-85048597541 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Cytokine | - |
dc.contributor.nonIdAuthor | Bucher, Felicitas | - |
dc.contributor.nonIdAuthor | Lee, Jungho | - |
dc.contributor.nonIdAuthor | Shin, Sanghee | - |
dc.contributor.nonIdAuthor | Ha, Sanghoon | - |
dc.contributor.nonIdAuthor | Zhang, Hongkai | - |
dc.identifier.citationVolume | 110 | - |
dc.identifier.citationStartPage | 397 | - |
dc.identifier.citationEndPage | 403 | - |
dc.identifier.citationTitle | Cytokine | - |
dc.type.journalArticle | Article in Press | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Interleukin-5 | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Endothelial | - |
dc.subject.keywordAuthor | STAT5 | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | POTENT PROMOTER | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | ANTI-VEGF | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.contributor.affiliatedAuthor | Bucher, Felicitas | - |
dc.contributor.affiliatedAuthor | Lee, Jungho | - |
dc.contributor.affiliatedAuthor | Shin, Sanghee | - |
dc.contributor.affiliatedAuthor | Kim, Minseok S. | - |
dc.contributor.affiliatedAuthor | Oh, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Ha, Sanghoon | - |
dc.contributor.affiliatedAuthor | Zhang, Hongkai | - |
dc.contributor.affiliatedAuthor | Yea, Kyungmoo | - |
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