Cited 19 time in webofscience Cited 21 time in scopus

A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels

Title
A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels
Authors
Yeon, JihyeKim, JinmahnKim, Do-YoungKim, HyunminKim, Jung HaDu, Eun JoKang, Kyeong JinLim, Hyun HoMoon, DaewonKim, Kyuhyung
DGIST Authors
Kim, HyunminMoon, DaewonKim, Kyuhyung
Issue Date
2018-06
Citation
PLoS Biology, 16(6)
Type
Article
Article Type
Article
Keywords
NEMATODE CAENORHABDITIS-ELEGANSCENTRAL PATTERN GENERATORSION CHANNELSMECHANOTRANSDUCTION CHANNELGENETIC-ANALYSISSKELETAL-MUSCLEDROSOPHILALOCOMOTIONPROTEINFEEDBACK
ISSN
1544-9173
Abstract
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient receptor potential cation (TRPC) channels, trp-1 and trp-2, as necessary and sufficient for proprioceptive responses in C. elegans head steering locomotion. Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions. Moreover, the SMDD neurons play dual roles to sense muscle stretch as well as to control muscle contractions. These results demonstrate that distinct locomotion patterns require dynamic and homeostatic modulation of feedback signals between neurons and muscles. © 2018 Yeon et al. http://creativecommons.org/licenses/by/4.0/
URI
http://hdl.handle.net/20.500.11750/9026
DOI
10.1371/journal.pbio.2004929
Publisher
Public Library of Science
Related Researcher
  • Author Kim, Kyuhyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
Files:
Collection:
Department of New BiologyNanoBio Imaging Laboratory1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles
Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


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