Cited 5 time in webofscience Cited 4 time in scopus

Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans

Title
Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans
Authors
Ryu, Lee sunCheon, Yong JinHuh, Yang HoonPyo, Seon DongChinta, SatyaChoi, Hong SooButcher, Rebecca A.Kim, Kyu Hyung
DGIST Authors
Choi, Hong SooKim, Kyu Hyung
Issue Date
2018-08
Citation
EMBO Journal, 37(15)
Type
Article
Article Type
Article
Author Keywords
avoidance behaviorDAF-2 insulin receptorfeeding statepheromonesynaptic transmission
Keywords
C-ELEGANSDEFECTIVE-MUTANTSOLFACTORY NEURONSRESPONSESEXPRESSIONGENESDAF-2NEUROPEPTIDESCOMMUNICATIONATTRACTION
ISSN
0261-4189
Abstract
Animals change sensory responses and their eventual behaviors, depending on their internal metabolic status and external food availability. However, the mechanisms underlying feeding state-dependent behavioral changes remain undefined. Previous studies have shown that Caenorhabditis elegans hermaphrodite exhibits avoidance behaviors to acute exposure of a pheromone, ascr#3 (asc-ΔC9, C9). Here, we show that the ascr#3 avoidance behavior is modulated by feeding state via the insulin signaling pathway. Starvation increases ascr#3 avoidance behavior, and loss-of-function mutations in daf-2 insulin-like receptor gene dampen this starvation-induced ascr#3 avoidance behavior. DAF-2 and its downstream signaling molecules, including the DAF-16 FOXO transcription factor, act in the ascr#3-sensing ADL neurons to regulate synaptic transmission to downstream target neurons, including the AVA command interneurons. Moreover, we found that starvation decreases the secretion of INS-18 insulin-like peptides from the intestine, which antagonizes DAF-2 function in the ADL neurons. Altogether, this study provides insights about the molecular communication between intestine and sensory neurons delivering hunger message to sensory neurons, which regulates avoidance behavior from pheromones to facilitate survival chance. © 2018 The Authors
URI
http://hdl.handle.net/20.500.11750/9233
DOI
10.15252/embj.201798402
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles
Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


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