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dc.contributor.author Lee, Hyoryong -
dc.contributor.author Choi, Hyunchul -
dc.contributor.author Lee, Mikyoung -
dc.contributor.author Park, Sukho -
dc.date.accessioned 2018-12-05T07:52:56Z -
dc.date.available 2018-12-05T07:52:56Z -
dc.date.created 2018-11-15 -
dc.date.issued 2018-11 -
dc.identifier.issn 1387-2176 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/9445 -
dc.description.abstract Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery. In this study, we propose a spring type medical microrobot that can be manipulated by an electromagnetic actuation (EMA) system and respond to an external stimulus (NIR). Additionally, we verified its feasibility with regard to targeting and drug delivery. There exist various methods of fabricating a spring type microrobot. In this study, we adopted a simple method that entails using a perfluoroalkoxy (PFA) microtube and a syringe pump. Moreover, we also used a hydrogel mixture composed of natural alginate, N-Isopropylacrylamide (NIPAM) for temperature responsiveness, and magnetic nanoparticles (MNPs) for electromagnetic control. Then, we fabricated a spring type alginate/NIPAM hydrogel-based soft microrobot. Additionally, we encapsulated doxorubicin (DOX) for tumor therapy in the microrobot. To verify the feasibility of the proposed spring type hydrogel-based soft microrobot’s targeting and drug delivery, we developed an EMA and NIR integrated system. Finally, we observed the swelling and deswelling of the soft microrobot under NIR stimulation and verified the EMA controlled targeting. Moreover, we implemented a control function to release the encapsulated anticancer drug (DOX) through the swelling and deswelling of the soft microrobot by NIR, and evaluated the feasibility of cancer cell therapy by controlling the release of the drug from the soft microrobot. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. -
dc.language English -
dc.publisher Springer US -
dc.title Preliminary Study on Alginate/NIPAM Hydrogel-based Soft Microrobot for Controlled Drug Delivery Using Electromagnetic Actuation and Near-Infrared Stimulus -
dc.type Article -
dc.identifier.doi 10.1007/s10544-018-0344-y -
dc.identifier.scopusid 2-s2.0-85058075882 -
dc.identifier.bibliographicCitation Biomedical Microdevices, v.20, no.1, pp.1 - 9 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor Controlled drug releasing -
dc.subject.keywordAuthor Electromagnetic actuation -
dc.subject.keywordAuthor Hydrogel-based microrobot -
dc.subject.keywordAuthor Magnetic nanoparticles -
dc.subject.keywordAuthor Near-infrared stimulus -
dc.subject.keywordAuthor Temperature responsive -
dc.subject.keywordPlus FABRICATION -
dc.subject.keywordPlus CELL -
dc.citation.endPage 9 -
dc.citation.number 1 -
dc.citation.startPage 1 -
dc.citation.title Biomedical Microdevices -
dc.citation.volume 20 -
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Department of Robotics and Mechatronics Engineering Multiscale Biomedical Robotics Laboratory 1. Journal Articles

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