Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Choi, Ja Eun | - |
dc.contributor.author | Kim, Somi | - |
dc.contributor.author | Lee, Jisu | - |
dc.contributor.author | Kim, Kyungjin | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2018-12-05T07:53:05Z | - |
dc.date.available | 2018-12-05T07:53:05Z | - |
dc.date.created | 2018-11-23 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | Experimental Neurobiology, v.27, no.5, pp.344 - 349 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9451 | - |
dc.description.abstract | Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms. One of the genes responsible for generating the circadian rhythm is Rev-ERB alpha. The REV-ERB alpha protein is a nuclear receptor that acts as a transcriptional repressor, and is a core component of the circadian clock. However, the role of REV-ERB alpha in neurophysiological processes in the hippocampus has not been characterized yet. In this study, we examined the time-dependent role of REV-ERB alpha in hippocampal synaptic plasticity using Rev-ERB alpha KO mice. The KO mice lacking REV-ERB alpha displayed abnormal NMDAR-dependent synaptic potentiation (E-LTP) at CT12 similar to CT14 (subjective night) when compared to their wild-type littermates. However, Rev-ERB alpha KO mice exhibited normal E-LTP at CT0 similar to CT2 (subjective day). We also found that the Rev-ERB alpha KO mice had intact late LTP (L-LTP) at both subjective day and night. Taken together, these results provide evidence that REV-ERB alpha is critical for hippocampal E-LTP during the dark period. | - |
dc.language | English | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Circadian Regulation by REV-ERB alpha Mediates Hippocampal E-LTP in a Time-dependent Manner | - |
dc.type | Article | - |
dc.identifier.doi | 10.5607/en.2018.27.5.344 | - |
dc.identifier.wosid | 000449529100002 | - |
dc.identifier.scopusid | 2-s2.0-85056592931 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Experimental Neurobiology | - |
dc.identifier.kciid | ART002401546 | - |
dc.contributor.nonIdAuthor | Choi, Ja Eun | - |
dc.contributor.nonIdAuthor | Kim, Somi | - |
dc.contributor.nonIdAuthor | Lee, Jisu | - |
dc.contributor.nonIdAuthor | Kim, Kyungjin | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.identifier.citationVolume | 27 | - |
dc.identifier.citationNumber | 5 | - |
dc.identifier.citationStartPage | 344 | - |
dc.identifier.citationEndPage | 349 | - |
dc.identifier.citationTitle | Experimental Neurobiology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Circadian clock system | - |
dc.subject.keywordAuthor | Circadian rhythm | - |
dc.subject.keywordAuthor | Neuronal plasticity | - |
dc.subject.keywordAuthor | Long-term potentiation | - |
dc.subject.keywordPlus | TERM-MEMORY FORMATION | - |
dc.subject.keywordPlus | CLOCK GENE | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | MICE | - |
dc.contributor.affiliatedAuthor | Choi, Ja Eun | - |
dc.contributor.affiliatedAuthor | Kim, Somi | - |
dc.contributor.affiliatedAuthor | Lee, Jisu | - |
dc.contributor.affiliatedAuthor | Kim, Kyungjin | - |
dc.contributor.affiliatedAuthor | Kaang, Bong-Kiun | - |
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