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dc.contributor.author Choi, Ja Eun -
dc.contributor.author Kim, Somi -
dc.contributor.author Lee, Jisu -
dc.contributor.author Kim, Kyungjin -
dc.contributor.author Kaang, Bong-Kiun -
dc.date.accessioned 2018-12-05T07:53:05Z -
dc.date.available 2018-12-05T07:53:05Z -
dc.date.created 2018-11-23 -
dc.date.issued 2018-10 -
dc.identifier.citation Experimental Neurobiology, v.27, no.5, pp.344 - 349 -
dc.identifier.issn 1226-2560 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/9451 -
dc.description.abstract Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms. One of the genes responsible for generating the circadian rhythm is Rev-ERB alpha. The REV-ERB alpha protein is a nuclear receptor that acts as a transcriptional repressor, and is a core component of the circadian clock. However, the role of REV-ERB alpha in neurophysiological processes in the hippocampus has not been characterized yet. In this study, we examined the time-dependent role of REV-ERB alpha in hippocampal synaptic plasticity using Rev-ERB alpha KO mice. The KO mice lacking REV-ERB alpha displayed abnormal NMDAR-dependent synaptic potentiation (E-LTP) at CT12 similar to CT14 (subjective night) when compared to their wild-type littermates. However, Rev-ERB alpha KO mice exhibited normal E-LTP at CT0 similar to CT2 (subjective day). We also found that the Rev-ERB alpha KO mice had intact late LTP (L-LTP) at both subjective day and night. Taken together, these results provide evidence that REV-ERB alpha is critical for hippocampal E-LTP during the dark period. -
dc.language English -
dc.publisher 한국뇌신경과학회 -
dc.title Circadian Regulation by REV-ERB alpha Mediates Hippocampal E-LTP in a Time-dependent Manner -
dc.type Article -
dc.identifier.doi 10.5607/en.2018.27.5.344 -
dc.identifier.wosid 000449529100002 -
dc.identifier.scopusid 2-s2.0-85056592931 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Experimental Neurobiology -
dc.identifier.kciid ART002401546 -
dc.contributor.nonIdAuthor Choi, Ja Eun -
dc.contributor.nonIdAuthor Kim, Somi -
dc.contributor.nonIdAuthor Lee, Jisu -
dc.contributor.nonIdAuthor Kim, Kyungjin -
dc.contributor.nonIdAuthor Kaang, Bong-Kiun -
dc.identifier.citationVolume 27 -
dc.identifier.citationNumber 5 -
dc.identifier.citationStartPage 344 -
dc.identifier.citationEndPage 349 -
dc.identifier.citationTitle Experimental Neurobiology -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor Circadian clock system -
dc.subject.keywordAuthor Circadian rhythm -
dc.subject.keywordAuthor Neuronal plasticity -
dc.subject.keywordAuthor Long-term potentiation -
dc.subject.keywordPlus TERM-MEMORY FORMATION -
dc.subject.keywordPlus CLOCK GENE -
dc.subject.keywordPlus PLASTICITY -
dc.subject.keywordPlus MICE -
dc.contributor.affiliatedAuthor Choi, Ja Eun -
dc.contributor.affiliatedAuthor Kim, Somi -
dc.contributor.affiliatedAuthor Lee, Jisu -
dc.contributor.affiliatedAuthor Kim, Kyungjin -
dc.contributor.affiliatedAuthor Kaang, Bong-Kiun -
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