Cited 4 time in webofscience Cited 5 time in scopus

Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells

Title
Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells
Authors
Yu, JinyeongKim, Hye MinKim, Kwang PyoSon, YoungsookKim, Min-SikPark, Ki-Sook
DGIST Authors
Kim, Min-Sik
Issue Date
2019-01
Citation
Biochemical and Biophysical Research Communications, 508(2), 361-367
Type
Article
Article Type
Article
Author Keywords
Ceramide kinaseMesenchymal stem cellsMigrationN-cadherinTGF-β
ISSN
0006-291X
Abstract
Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of intrinsic lipid kinases of BM-MSCs in the stem cell migration are unclear. Here, we demonstrated that ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-β. Furthermore, a specific inhibitor of ceramide kinase inhibited TGF-β-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-β. Therefore, these results suggest that the intracellular ceramide kinase is required for the BM-MSCs migration and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation. © 2018
URI
http://hdl.handle.net/20.500.11750/9481
DOI
10.1016/j.bbrc.2018.11.154
Publisher
Academic Press
Related Researcher
  • Author Kim, Min-Sik Laboratory for QBIO and Precision Medicine
  • Research Interests Cancer Proteogenomics, Biomarker Discovery, Integrative Multi-Omics
Files:
There are no files associated with this item.
Collection:
Department of New BiologyLaboratory for QBIO and Precision Medicine1. Journal Articles


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