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DC Field Value Language Yu, Jinyeong - Kim, Hye Min - Kim, Kwang Pyo - Son, Youngsook - Kim, Min-Sik - Park, Ki-Sook - 2019-01-16T14:51:21Z - 2019-01-16T14:51:21Z - 2018-12-07 - 2019-01 -
dc.identifier.citation Biochemical and Biophysical Research Communications, v.508, no.2, pp.361 - 367 -
dc.identifier.issn 0006-291X -
dc.identifier.uri -
dc.description.abstract Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of intrinsic lipid kinases of BM-MSCs in the stem cell migration are unclear. Here, we demonstrated that ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-β. Furthermore, a specific inhibitor of ceramide kinase inhibited TGF-β-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-β. Therefore, these results suggest that the intracellular ceramide kinase is required for the BM-MSCs migration and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation. © 2018 -
dc.language English -
dc.publisher Academic Press -
dc.title Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells -
dc.type Article -
dc.identifier.doi 10.1016/j.bbrc.2018.11.154 -
dc.identifier.wosid 000456635900004 -
dc.identifier.scopusid 2-s2.0-85057293726 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Biochemical and Biophysical Research Communications -
dc.contributor.nonIdAuthor Yu, Jinyeong -
dc.contributor.nonIdAuthor Kim, Hye Min -
dc.contributor.nonIdAuthor Kim, Kwang Pyo -
dc.contributor.nonIdAuthor Son, Youngsook -
dc.contributor.nonIdAuthor Park, Ki-Sook -
dc.identifier.citationVolume 508 -
dc.identifier.citationNumber 2 -
dc.identifier.citationStartPage 361 -
dc.identifier.citationEndPage 367 -
dc.identifier.citationTitle Biochemical and Biophysical Research Communications -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Ceramide kinase -
dc.subject.keywordAuthor Mesenchymal stem cells -
dc.subject.keywordAuthor Migration -
dc.subject.keywordAuthor N-cadherin -
dc.subject.keywordAuthor TGF-β -
dc.contributor.affiliatedAuthor Yu, Jinyeong -
dc.contributor.affiliatedAuthor Kim, Hye Min -
dc.contributor.affiliatedAuthor Kim, Kwang Pyo -
dc.contributor.affiliatedAuthor Son, Youngsook -
dc.contributor.affiliatedAuthor Kim, Min-Sik -
dc.contributor.affiliatedAuthor Park, Ki-Sook -
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Department of New Biology Laboratory for QBIO and Precision Medicine 1. Journal Articles


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