Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Yu, Jinyeong | - |
dc.contributor.author | Kim, Hye Min | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Son, Youngsook | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.contributor.author | Park, Ki-Sook | - |
dc.date.accessioned | 2019-01-16T14:51:21Z | - |
dc.date.available | 2019-01-16T14:51:21Z | - |
dc.date.created | 2018-12-07 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9481 | - |
dc.description.abstract | Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of intrinsic lipid kinases of BM-MSCs in the stem cell migration are unclear. Here, we demonstrated that ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-β. Furthermore, a specific inhibitor of ceramide kinase inhibited TGF-β-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-β. Therefore, these results suggest that the intracellular ceramide kinase is required for the BM-MSCs migration and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation. © 2018 | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.title | Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.11.154 | - |
dc.identifier.scopusid | 2-s2.0-85057293726 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.508, no.2, pp.361 - 367 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Ceramide kinase | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | N-cadherin | - |
dc.subject.keywordAuthor | TGF-β | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MOBILIZATION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.citation.endPage | 367 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 361 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 508 | - |
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