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Intracellular protein complexes involved in synapse assembly in presynaptic neurons

Title
Intracellular protein complexes involved in synapse assembly in presynaptic neurons
Authors
Han, Kyung AhUm, Ji WonKo, Jaewon
DGIST Authors
Han, Kyung Ah; Um, Ji WonKo, Jaewon
Issue Date
2019-05
Citation
Advances in Protein Chemistry and Structural Biology, 116, 347-373
Type
Article
Article Type
Review; Book Chapter
Author Keywords
LARLigandsNeurexinPresynaptic active zonePTPδPTPσSynapse developmentSynaptic adhesion
Keywords
GTPASE-ACTIVATING-PROTEINBETA-CATENINLIPRIN-ALPHAACTIVE ZONETYROSINE-PHOSPHATASEMOLECULAR-MECHANISMSDROSOPHILA SYD-1SEPTATE JUNCTIONHEPARAN-SULFATEKINASE DOMAIN
ISSN
1876-1623
Abstract
The presynaptic active zone, composed of evolutionarily conserved protein complexes, is a specialized area that serves to orchestrate precise and efficient neurotransmitter release by organizing various presynaptic proteins involved in mediating docking and priming of synaptic vesicles, recruiting voltage-gated calcium channels, and modulating presynaptic nerve terminals with aligned postsynaptic structures. Among membrane proteins localized to active zone, presynaptic neurexins and LAR-RPTPs (leukocyte common antigen-related receptor tyrosine phosphatase) have emerged as hubs that orchestrate both shared and distinct extracellular synaptic adhesion pathways. In this chapter, we discuss intracellular signaling cascades involved in recruiting various intracellular proteins at both excitatory and inhibitory synaptic sites. In particular, we highlight recent studies on key active zone proteins that physically and functionally link these cascades with neurexins and LAR-RPTPs in both vertebrate and invertebrate model systems. These studies allow us to build a general, universal view of how presynaptic active zones operate together with postsynaptic structures in neural circuits. © 2018 Elsevier Inc.
URI
http://hdl.handle.net/20.500.11750/9524
DOI
10.1016/bs.apcsb.2018.11.008
Publisher
Academic Press Inc.
Related Researcher
  • Author Ko, Jaewon Laboratory of Synapse Formation and Function
  • Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
Files:
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Collection:
Department of Brain and Cognitive SciencesSynapse Disorder Laboratory1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Synapse Formation and Function1. Journal Articles


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